Evidence map›Paper›PMID 39345485›Full record

ArticlebioRxiv : the preprint server for biology2024

Truncated Complement Factor H Y402 Gene Therapy Cures C3 Glomerulonephritis.

Lindsey A Chew, Daniel Grigsby, C Garren Hester, Joshua Amason, W Kyle McPherson, Edward J Flynn, Meike Visel, John G Flannery, Catherine Bowes Rickman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lindsey A ChewDepartment of Ophthalmology, Duke Eye Center, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-2040-1579
Daniel GrigsbyGenetically Engineered Murine Model (GEMM) Core, University of Virginia, Charlottesville, VA, 22903.
C Garren HesterDepartment of Ophthalmology, Duke Eye Center, Duke University Medical Center, Durham, NC 27710.
Joshua AmasonDepartment of Ophthalmology, Duke Eye Center, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0001-8459-7243
W Kyle McPhersonDepartment of Ophthalmology, Duke Eye Center, Duke University Medical Center, Durham, NC 27710.
Edward J FlynnDepartment of Ophthalmology, Duke Eye Center, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-2573-6837
Meike ViselDepartment of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, 94720.
John G FlanneryDepartment of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, 94720.ORCID 0000-0002-0720-8897
Catherine Bowes RickmanDepartment of Ophthalmology, Duke Eye Center, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-8555-9596

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
Complement factor H modulates lipoprotein clearance in AMDR01EY031748 · NEI · DUKE UNIVERSITY · PI BOWES RICKMAN, CATHERINE · 2020 to 2024
$2.8M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY031748
6 · The paper itself

Abstract

Patients with both age-related macular degeneration (AMD) and C3 glomerulonephritis (C3G) are challenged by the absence of effective therapies to reverse and eliminate their disease burden. Capitalizing on complement dysregulation as both a significant risk factor for AMD and the known pathophysiology of C3G, we investigated the potential for adeno-associated virus (AAV) delivery of complement factor H (CFH) to rescue C3G in a

Indexed as

age-related macular degenerationC3 glomerulonephritisC3 glomerulopathycomplement factor Hcomplement regulationgene replacementgene therapy

Identifiers

PMID39345485
PMCPMC11429740

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.