Evidence map›Paper›PMID 39345868›Full record

ArticleJournal of the Endocrine Society2024

The Subcutaneous Adipose Microenvironment as a Determinant of Body Fat Development in Polycystic Ovary Syndrome.

Daniel A Dumesic, Melody A Rasouli, Jessica D Katz, Gwyneth G Lu, Devyani Dharanipragada, Adina F Turcu, Tristan R Grogan, Kimberly E Flores, Clara E Magyar, David H Abbott and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel A DumesicDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0003-0387-1277
Melody A RasouliDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jessica D KatzDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Gwyneth G LuDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Devyani DharanipragadaDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Adina F TurcuDivision of Metabolism, Endocrinology, Nutrition and Diabetes, University of Michigan, Ann Arbor, MI 48103, USA.
Tristan R GroganDepartment of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, CA 90024, USA.ORCID https://orcid.org/0000-0001-9471-2938
Kimberly E FloresDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Clara E MagyarDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
David H AbbottDepartment of Obstetrics and Gynecology, Wisconsin National Primate Research Center, University of Wisconsin, Madison, Madison, WI 53715, USA.ORCID https://orcid.org/0000-0002-8249-263X
Gregorio D ChazenbalkDepartment of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
PROJECT 4: ANDROGEN EXCESS IN ADIPOGENIC DYSFUNCTION IN PCOS WOMENP50HD071836 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI HENNEBOLD, JON D · 2014 to 2021
$14.7M
11-Oxyandrogens and Aging: Health ImplicationsR01AG080516 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Adina F Turcu · 2023 to 2026
$2.3M
NCATS NIH HHS UL1 TR001881NIA NIH HHS R01 AG080516NICHD NIH HHS P50 HD071836NIH HHS P51 OD011092
6 · The paper itself

Abstract

Context: Adipose steroid metabolism modifies body fat development in polycystic ovary syndrome (PCOS). Objective: To determine whether subcutaneous (SC) abdominal adipose aldo-keto reductase 1C3 (AKR1C3; a marker of testosterone generation) is increased in normal-weight women with PCOS vs age- and body mass index (BMI)-matched normoandrogenic ovulatory women (controls) and is related to SC abdominal adipose activator protein-1 (AP-1; a marker of adipocyte differentiation) and/or androgen receptor (AR) protein expression in predicting fat accretion. Design: Prospective cohort study. Setting: Academic center. Patients: Eighteen normal-weight PCOS women; 17 age- and BMI-matched controls. Interventions: Circulating hormone/metabolic determinations, intravenous glucose tolerance testing, total body dual-energy x-ray absorptiometry, SC abdominal fat biopsy, immunohistochemistry. Main Outcome Measures: Clinical characteristics, hormonal concentrations, body fat distribution, SC adipose AKR1C3, AR, and AP-1 protein expression. Results: Women with PCOS had significantly higher serum androgen levels and greater android/gynoid fat mass ratios than controls. SC adipose AKR1C3, AR, and AP-1 protein expressions were comparable between the study groups, but groups differed in correlations. In PCOS women vs controls, SC adipose AKR1C3 protein expression correlated positively with android and gynoid fat masses and negatively with SC adipose AP-1 protein expression. SC adipose AR protein expression correlated negatively with fasting serum free fatty acid and high-density lipoprotein levels. In both study groups, SC adipose AKR1C3 protein expression negatively correlated with serum cortisol levels. Conclusion: In normal-weight PCOS women, SC abdominal adipose AKR1C3 protein expression, in combination with intra-adipose AP-1 and AR-dependent events, predicts fat accretion in the presence of physiological cortisol levels.

Indexed as

activator protein-1adiposealdo-keto reductase 1C3androgen receptorcortisolpolycystic ovary syndrome

Identifiers

PMID39345868
PMCPMC11424691

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.