Evidence map›Paper›PMID 39348098›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2024

Tobacco Biomarkers by Latino Heritage and Race, US, 2007 to 2014 National Health and Nutrition Examination Survey.

Chelsea Duong, Erik J Rodriquez, Amanda S Hinerman, Somy Hooshmand, Sophie E Claudel, Neal L Benowitz, Eliseo J Pérez-Stable

Abstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chelsea DuongDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0009-0002-5300-135X
Erik J RodriquezDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-7456-4218
Amanda S HinermanDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0001-8167-2463
Somy HooshmandDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-1080-2042
Sophie E ClaudelDepartment of Internal Medicine, Boston Medical Center, Boston, Massachusetts.ORCID 0000-0002-7695-4674
Neal L BenowitzResearch Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California.ORCID 0000-0003-2041-8124
Eliseo J Pérez-StableDivision of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-1577-2738

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Torsten Brian Neilands · 1997 to 2026
$19.5M
REDES EN ACCION--CANCER AWARENESS, TRAINING AND RESEARCHU01CA086117 · NCI · BAYLOR COLLEGE OF MEDICINE · PI RAMIREZ, AMELIE G · 2000 to 2005
$9.0M
Training ProgramU54CA153511 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RAMIREZ, AMELIE G · 2010 to 2015
$6.2M
Intramural NIH HHS Z99 OD999999Intramural NIH HHS ZIA HL006287National Cancer Institute (NCI) U01 CA86117National Center for Advancing Translational Sciences (NCATS) UL1 RR024131-0XNational Institute on Aging (NIA) P30 AG15272National Institutes of Health (NIH) Medical Research Scholars ProgramNational Institutes of Health (NIH) Z01 HL006287NCI NIH HHS U01 CA086117NCI NIH HHS U54 CA153511NCRR NIH HHS UL1 RR024131NIA NIH HHS P30 AG015272
6 · The paper itself

Abstract

backgroundTobacco biomarkers reflect smoking intensity and are used to assess cessation status. No study has evaluated variation by Latino heritage.

methodsData from the 2007 to 2014 National Health and Nutrition Examination Survey were used to evaluate geometric mean concentrations of serum cotinine and urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), stratified by smoking status and race and ethnicity, and ROC curves estimated values to distinguish smokers from nonsmokers by race and ethnicity and Latino heritage.

resultsThe sample (n = 18,597) was 50.1% female, 16.6% Latino (58.6% Mexican, 10.4% Central American, 9.1% South American, 7.3% Puerto Rican, 3.5% Dominican, 2.7% Cuban, and 8.4% other Latinos, overall), 12.7% Black, and 70.7% White. Black nonsmokers and smokers had the highest cotinine concentrations (0.1 and 177.1 ng/mL), and among nonsmokers, Black individuals had the highest NNAL concentrations (1.4 pg/mL). Latino smokers had the lowest cotinine (32.7 ng/mL) and NNAL (63.9 pg/mL) concentrations. Among Latino smokers, Puerto Rican individuals had higher concentrations of cotinine (100.0 ng/mL) and NNAL (136.4 pg/mL). Cotinine levels defining smoking (Black: 9.1 ng/mL; Latino: 0.9 ng/mL; White: 3.8 ng/mL) and NNAL (Black: 24.1 pg/mL; Latino: 5.7 pg/mL; White: 15.5 pg/mL) varied. Puerto Rican adults (cotinine: 8.5 ng/mL; NNAL: 17.2 pg/mL) had higher levels than Central American (cotinine: 1.0 ng/mL, NNAL: 5.5 pg/mL) and Mexican (cotinine: 0.9 ng/mL, NNAL: 6.0 pg/mL) adults.

conclusionsCotinine and NNAL concentrations that define smoking differed by race and ethnicity and by heritage among Latinos, showing meaningful differences. IMPACT: Cessation interventions with biomarker validation need to consider Latino heritage.

Indexed as

BiomarkersCotinineHispanic or LatinoNutrition SurveysAdultAgedBlack or African AmericanFemaleHumansMaleMiddle AgedNitrosaminesSmokingUnited StatesWhiteYoung AdultBiomarkersCotinineNitrosamines

Identifiers

PMID39348098
PMCPMC11611627

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.