Evidence map›Paper›PMID 39348690›Full record

Trial reportAnnals of internal medicine2024

Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.

Emily N C Manoogian, Michael J Wilkinson, Monica O'Neal, Kyla Laing, Justina Nguyen, David Van, Ashley Rosander, Aryana Pazargadi, Nikko R Gutierrez, Jason G Fleischer and 3 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04057339 nacompletednot on this map

Influence of Time-restricted Eating (TRE) on Circadian Regulation of Glucose Homeostasis and Mitochondrial Function - The TIMET Study

TypeinterventionalSponsorUniversity of California, San DiegoRan2019 to 2024Enrolled122ConditionsMetabolic Syndrome, Pre-DiabetesArmsTime Restricted Eating + Standard of Care, Standard of Care
NCT07389603 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of a Restricted Time and Psychochrononutritional Feeding Intervention Program on the Nutritional Status of People With Metabolic Syndrome in Ciudad Guzmán

TypeinterventionalSponsorUniversity of GuadalajaraRan2025 to 2026Enrolled64ConditionsMetabolic SyndromeArmsTime restricted eating, Psychochrononutritional intervention
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  16. Meal Timing Patterns and Associations with Fat Mass in Adolescents.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emily N C ManoogianRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, California (E.N.C.M., M.O., K.L., N.R.G., S.P.).ORCID 0000-0001-9718-9310
Michael J WilkinsonDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California (M.J.W., J.N., D.V., A.R., A.P., P.R.T.).ORCID 0000-0002-3800-7369
Monica O'NealRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, California (E.N.C.M., M.O., K.L., N.R.G., S.P.).
Kyla LaingRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, California (E.N.C.M., M.O., K.L., N.R.G., S.P.).
Justina NguyenDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California (M.J.W., J.N., D.V., A.R., A.P., P.R.T.).
David VanDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California (M.J.W., J.N., D.V., A.R., A.P., P.R.T.).ORCID 0000-0002-5188-0226
Ashley RosanderDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California (M.J.W., J.N., D.V., A.R., A.P., P.R.T.).
Aryana PazargadiDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California (M.J.W., J.N., D.V., A.R., A.P., P.R.T.).
Nikko R GutierrezRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, California (E.N.C.M., M.O., K.L., N.R.G., S.P.).
Jason G FleischerDepartment of Cognitive Science, University of California, San Diego, La Jolla, California (J.G.F.).ORCID 0000-0001-9462-9333
Shahrokh GolshanDepartment of Psychiatry, University of California, San Diego, La Jolla, California (S.G.).
Satchidananda PandaRegulatory Biology, The Salk Institute for Biological Studies, La Jolla, California (E.N.C.M., M.O., K.L., N.R.G., S.P.).ORCID 0000-0002-7855-0091
Pam R TaubDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California (M.J.W., J.N., D.V., A.R., A.P., P.R.T.).ORCID 0000-0002-0684-0655

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TONY R. HUNTER · 1985 to 2026
$82.8M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Impact of Time-Restricted Feeding (TRF) on Glucose Homeostasis and Mitochondrial Function in Patients with Metabolic SyndromeR01DK118278 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pam Rajendran Taub · 2018 to 2026
$5.3M
Impact of Time-Restricted Feeding in Reducing Cancer Risk Through Optimizing Mitochondria FunctionR01CA258221 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2021 to 2025
$3.8M
NCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR001442NCI NIH HHS P30 CA014195NCI NIH HHS R01 CA258221NIDDK NIH HHS R01 DK118278
6 · The paper itself

Abstract

backgroundTime-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.

objectiveTo determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.

designRandomized controlled trial. (ClinicalTrials.gov: NCT04057339).

settingClinical research institute.

participantsAdults with metabolic syndrome including elevated fasting glucose or hemoglobin A

interventionParticipants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application. MEASUREMENTS: Primary outcomes were HbA

results108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m LIMITATION: Short duration, self-reported diet, potential for multiple elements affecting outcomes.

conclusionPersonalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling. PRIMARY FUNDING SOURCE: National Institutes of Health.

Indexed as

Blood GlucoseGlycated HemoglobinMetabolic SyndromeAdultCaloric RestrictionCounselingFastingFemaleHumansInsulinInsulin ResistanceMaleMiddle AgedTime FactorsBlood GlucoseGlycated HemoglobinInsulin

Identifiers

PMID39348690
PMCPMC11929607

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.