Evidence map›Paper›PMID 39349059›Full record

ArticleeNeuro2024

BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety.

Nicolette B Frazer, Garrett A Kaas, Caroline G Firmin, Eric R Gamazon, Antonis K Hatzopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicolette B FrazerVanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232.
Garrett A KaasDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
Caroline G FirminDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
Eric R GamazonVanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232.ORCID https://orcid.org/0000-0003-4204-8734
Antonis K HatzopoulosVanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232 antonis.hatzopoulos@vumc.org.ORCID https://orcid.org/0000-0001-5610-0017

Funding

NHGRI NIH HHS R01 HG011138NHLBI NIH HHS R01 HL138519NIA NIH HHS R56 AG068026
6 · The paper itself

Abstract

The Bone Morphogenetic Protein (BMP) signaling pathway is vital in neural progenitor cell proliferation, specification, and differentiation. The BMP signaling antagonist Gremlin 2 (Grem2) is the most potent natural inhibitor of BMP expressed in the adult brain; however its function remains unknown. To address this knowledge gap, we have analyzed mice lacking Grem2 via homologous recombination (

Indexed as

AnxietyBone Morphogenetic ProteinsHippocampusIntercellular Signaling Peptides and ProteinsMice, Inbred C57BLMice, KnockoutNeurogenesisSeizuresAnimalsCell ProliferationCytokinesFemaleMaleMiceNeural Stem CellsStress, PsychologicalBone Morphogenetic ProteinsCytokinesGrem2 protein, mouseIntercellular Signaling Peptides and ProteinsanxietyBMP signalingepilepsyGremlin 2hippocampal neurogenesis

Identifiers

PMID39349059
PMCPMC11493175

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.