Evidence map›Paper›PMID 39349484›Full record

ArticleScientific reports2024

Activity of exoglycosidases in blood, urine, cerebrospinal fluid, and vitreous humor in individuals who died from ethyl alcohol poisoning.

Iwona Ptaszyńska-Sarosiek, Agnieszka Kułak-Bejda, Anna Niemcunowicz-Janica, Napoleon Waszkiewicz, Urszula Cwalina, Miłosz Nesterowicz, Jurgita Stasiūnienė, Sławomir Dariusz Szajda, Sylwia Chojnowska, Michał Szeremeta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iwona Ptaszyńska-SarosiekDepartment of Forensic Medicine, Medical University of Bialystok, Waszyngtona 13, 15-269, Białystok, Poland. i.sarosiek@wp.pl.
Agnieszka Kułak-BejdaDepartment of Psychiatry, Medical University of Bialystok, Wołodyjowskiego 2, 15-272, Białystok, Poland.
Anna Niemcunowicz-JanicaDepartment of Forensic Medicine, Medical University of Bialystok, Waszyngtona 13, 15-269, Białystok, Poland.
Napoleon WaszkiewiczDepartment of Psychiatry, Medical University of Bialystok, Wołodyjowskiego 2, 15-272, Białystok, Poland.
Urszula CwalinaDepartment of Statistics and Medical Informatics, Medical University of Bialystok, Szpitalna 37, 15-295, Białystok, Poland.
Miłosz NesterowiczDepartment of Forensic Medicine, Medical University of Bialystok, Waszyngtona 13, 15-269, Białystok, Poland.
Jurgita StasiūnienėDepartment of Pathology, Forensic Medicine and Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, M. K. Čiurlionio G. 21, 03101, Vilnius, Lithuania.
Sławomir Dariusz SzajdaDepartment of Emergency Medical Service, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10-719, Olsztyn, Poland.
Sylwia ChojnowskaFaculty of Health Sciences, University of Lomza, Akademicka 14, 18-400, Łomża, Poland.
Michał SzeremetaDepartment of Forensic Medicine, Medical University of Bialystok, Waszyngtona 13, 15-269, Białystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysosomal exoglycosidases, namely α-mannosidase (MAN), α-fucosidase (FUC), β-galactosidase (GAL), and β-glucuronidase (GLU), are of crucial importance in breaking down the oligosaccharide chains of multiple glycoconjugates. Those enzymes liberate monosaccharides from non-reducing ends of oligosaccharide chains. In this study, we have aimed to assess the potential utility of MAN, FUC, GAL, and GLU activities as indicators of ethanol abuse in individuals who died from ethanol intoxication, while also investigating the mechanisms underlying their deaths. The study group comprised 22 fatal ethanol-intoxicated individuals, while the control group included 30 deceased individuals whose body fluids showed no traces of alcohol. We measured the activities (pKat/mL) of MAN, FUC, GAL, and GLU in the supernatants of blood, urine, cerebrospinal fluid as well as vitreous humor. The results indicated significantly lower activities of MAN (p = 0.003), FUC (p = 0.008), GAL (p = 0.014), and GLU (p = 0.004) in the urine of individuals poisoned by ethanol as compared to the control group. Additionally, there was a significantly lower activity of MAN in the vitreous of those affected by ethyl alcohol poisoning (p = 0.016).

Indexed as

EthanolVitreous BodyAdultAgedAlcoholismalpha-L-Fucosidasealpha-Mannosidasebeta-GalactosidaseFemaleGlucuronidaseGlycoside HydrolasesHumansMaleMiddle AgedYoung Adultalpha-L-Fucosidasealpha-Mannosidasebeta-GalactosidaseEthanolGlucuronidaseGlycoside Hydrolases

Identifiers

PMID39349484
PMCPMC11442469

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.