ArticleJournal of assisted reproduction and genetics2024
Pregnancy rate and time to pregnancy after recurrent implantation failure (RIF)-a prospective cohort follow-up study.
Article in Journal of assisted reproduction and genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence of pregnancy outcomes among patients with recurrent implantation failure: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Investigation of the effect of intrauterine injection of platelet-rich plasma (PRP) on the results of in vitro fertilization (IVF): A cohort study.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Evaluation of Th1-Th2 balance in patients with recurrent implantation failure; a systematic review and meta-analysis.BMC immunology · 2026Review
- Endometrial Dysfunction in Women with Ovarian and Uterine Tumors: What Is Known and What Should Be Learned?International journal of molecular sciences · 2026Review
- Classification of recurrent implantation failure patients using peripheral blood immunological and metabolic markers.BioImpacts : BI · 2026Article
- Clustering of Uterine Natural Killer Cells Around Uterine Glands in Women with Recurrent Implantation Failure and Recurrent Pregnancy Loss: An Immunohistochemical Study.International journal of molecular sciences · 2025Article
- Time-Lapse Imaging in IVF: Bridging the Gap Between Promises and Clinical Realities.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe goal of this study was to determine ongoing pregnancy rate, time to pregnancy and embryo transfers to pregnancy within a cohort of patients with recurrent implantation failure (RIF).
methodsIVF patients with RIF were included after referral to the RIF outpatient clinic. They received a questionnaire 1 year after inclusion. If data was missing, medical files were examined to determine pregnancy outcomes and conception methods. The ability of the RIF outpatient clinic to improve pregnancy chance or increase the number of patients who elected to continue treatment was beyond the scope of this study.
resultsThe cumulative incidence of ongoing pregnancy in IVF patients with RIF (n = 79) after 1 year of follow-up was 40.5% (95% confidence interval = 30.4-51.5%). Median time to pregnancy was 4 months. Pregnancy incidence increased gradually up to 5 embryo transfers (mostly single embryo transfers). The average embryo transfers to pregnancy were 7.3 transfers.
conclusionIn IVF patients with RIF, up until the 5th embryo transfer, each transfer represents a good opportunity for ongoing pregnancy. This data can be used to counsel patients that regular treatment continuation seems to be well justified even when IVF patients fulfil the RIF criteria.
trial registrationCCMO: NL66835.068.18. METC 18-040. OMON: NL-OMON24778.
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