Evidence map›Paper›PMID 39350183›Full record

ArticleBMC nutrition2024

Is fat mass a better predictor of 6-month survival than muscle mass among African children aged 6-59 months with severe pneumonia?

Damalie Nalwanga, Victor Musiime, Sarah Kiguli, Peter Olupot-Olupot, Florence Alaroker, Robert Opoka, Abner Tagoola, Hellen Mnjalla, Christabel Mogaka, Eva Nabawanuka and 4 more

Abstract read
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In one paragraph

Article in BMC nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Damalie NalwangaDepartment of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda. damalielwanga@gmail.com.
Victor MusiimeDepartment of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.
Sarah KiguliDepartment of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.
Peter Olupot-OlupotMbale Clinical Research Institute, Mbale, Uganda.
Florence AlarokerSoroti Regional Referral Hospital, Soroti, Uganda.
Robert OpokaDepartment of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.
Abner TagoolaJinja Regional Referral Hospital, Jinja, Uganda.
Hellen MnjallaKEMRI Wellcome Trust Research Programme, P. O. Box 230, Kilifi, Kenya.
Christabel MogakaKEMRI Wellcome Trust Research Programme, P. O. Box 230, Kilifi, Kenya.
Eva NabawanukaDepartment of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.
Elisa GiallongoIntensive Care National Audit & Research Centre, London, UK.
Charles KaramagiDepartment of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, P. O. Box 7072, Kampala, Uganda.
André BriendTampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland.
Kathryn MaitlandKEMRI Wellcome Trust Research Programme, P. O. Box 230, Kilifi, Kenya.

Funding

European and Developing Countries Clinical Trials Partnership RIA2016S-1636UK Joint Global Health Trials scheme: Medical Research Council, Department for International Development Wellcome Trust MR/L004364/1Wellcome Trust
6 · The paper itself

Abstract

backgroundPneumonia remains the leading cause of mortality among children under 5 years. Poor nutritional status increases pneumonia mortality. Nutritional status assessed by anthropometry alone does not provide information on which body composition element predicts survival. Body composition proxy measures including arm-fat-area (AFA), arm-muscle-area (AMA), and arm-muscle-circumference (AMC) could be useful predictors.

objectiveTo compare the ability of fat and muscle mass indices to predict 6-month survival among children with severe pneumonia.

methodsThis prospective cohort study was nested in the COAST-Nutrition trial (ISRCTN10829073, 06/06/2018) conducted between June 2020 and October 2022 in Uganda and Kenya. We included children aged 6-59 months hospitalized for severe pneumonia with hypoxemia. Children with severe malnutrition, known chronic lung or cardiac diseases were excluded. Anthropometry and clinical status were assessed at enrolment and at follow-up to day 180. We examined Receiver Operator Characteristic (ROC) curves of fat and muscle mass indices with 6-month survival as the outcome, and compared the areas under the curve (AUCs) using chi-square tests. Cox survival analysis models assessed time-to-mortality.

resultsWe included 369 participants. The median age was 15-months (IQR 9, 26), and 59.4% (219/369) of participants were male. The baseline measurements were: median MUAC 15.0 cm (IQR 14.0,16.0); arm-fat-area 5.6cm

conclusionsMuscle mass did not predict 6-month survival better than fat mass in children with severe pneumonia. Fat mass appears to be a better predictor. Effects of fat and muscle could be considered for prognosis and targeted interventions.

Indexed as

ChildrenFat massMortalityMuscle massPneumonia

Identifiers

PMID39350183
PMCPMC11441138

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.