Evidence map›Paper›PMID 39350192›Full record

ArticleBMC endocrine disorders2024

Risk and determinants of sarcopenia in people with diabetes: a case-control study from Qatar Biobank cohort.

Hibeh Shatila, Nour Ghazal, Ghalya Bukshaisha, Shaikha Al-Zeyara, Cosette Fakih El Khoury, Maya Bassil

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Article in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hibeh ShatilaDepartment of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Doha, Qatar.
Nour GhazalDepartment of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Doha, Qatar.
Ghalya BukshaishaDepartment of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Doha, Qatar.
Shaikha Al-ZeyaraDepartment of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Doha, Qatar.
Cosette Fakih El KhouryNational Institute of Public Health, Clinical Epidemiology, and Toxicology-Lebanon (INSPECT-LB), Beirut, Lebanon.
Maya BassilDepartment of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Doha, Qatar. bassil.maya@qu.edu.qa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes is associated with impairments in muscle mass and quality increasing the risk of sarcopenia. Thus, this study aimed to investigate the odds of sarcopenia and its associated risk factors among Qatari adults (> 18 years), while exploring the modulating effects of health and lifestyle factors.

methodsUsing a case-control design, data from 767 participants (481 cases with diabetes and 286 controls without diabetes) was collected from Qatar Biobank (QBB). Sociodemographic, lifestyle factors including dietary intake, anthropometric and biochemical measures were analyzed. Handgrip strength, Dual X-ray absorptiometry (DXA), and Bio-impedance were used to assess muscle strength, muscle mass and muscle quality, respectively. The risk of sarcopenia was estimated using the European consensus on definition and diagnosis of sarcopenia.

resultsCases with diabetes were older (55 vs. 36 years; P < 0.001), had higher BMI (31.6 vs. 28.3 kg/m2; P < 0.001), lower cardiorespiratory fitness (50.0% "Moderate" fitness for cases, 62.9% "High" fitness for controls), and consumed less total (59.0 vs. 64.0; P = 0.004) and animal protein (39.0 vs. 42.0; P = 0.001), compared to controls based on a computed score. Participants with diabetes also had lower appendicular lean mass/BMI, handgrip strength, and higher probability of sarcopenia/probable sarcopenia (P < 0.005). Adjusted multiple logistic regression revealed that elevated cardiorespiratory fitness (β = 0.299, 95%CI:0.12-0.74) and blood triglycerides (β = 1.475, 95% CI: 1.024-2.124), as well as being a female (β = 0.086, 95%CI: 0.026-0.288) and having higher BMI (β = 0.908, 95%CI: 0.852-0.967) and ALM/BMI (β = 0.000, 95% CI: 0.000-0.007) are independent predictors (p < 0.05) of sarcopenia risk.

conclusionsThis study highlights the intricate relationship between diabetes and sarcopenia, revealing modifiable risk factors. Individuals with diabetes were found to have a higher likelihood of sarcopenia, which was associated with lower fitness levels and higher blood triglycerides. Protective factors against sarcopenia included being female and having higher BMI and ALM/BMI ratios.

Indexed as

Biological Specimen BanksSarcopeniaAdultAgedCase-Control StudiesCohort StudiesDiabetes MellitusFemaleFollow-Up StudiesHand StrengthHumansMaleMiddle AgedPrognosisQatarRisk FactorsAppendicular lean massBMICardiorespiratory fitnessDiabetesProtein intakeSarcopenia

Identifiers

PMID39350192
PMCPMC11440684

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.