Evidence map›Paper›PMID 39350195›Full record

ArticleTrials2024

Role of the screening with coronary computed tomography angiography on lipid management and risk factors control in an asymptomatic Chinese population: a community-based, parallel-group, open-label, randomized clinical trial (RESPECT2).

Xiang Guo, Jianhua Li, Ying Zhu, Yanming Li, Jingzhou Jiang, Rui Zuo, Wei Xu, Junqing Ma, Chao Li, Jialuo Yang and 20 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05725096 (Role of the Screening with Coronary Computed Tomography Angiography on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05725096 narecruitingnot on this map

Role of the Screening with Coronary Computed Tomography Angiography on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population: a Community-based, Prospective Randomised Trial

TypeinterventionalSponsorZhang longjiang,MDRan2023 to 2027Enrolled3,400ConditionsStatin, Cardiovascular Risk Factors, Primary Prevention, Adherence, MedicationArmsCoronary Computed Tomography Angiography, Traditional cardiovascular risk stratification
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Xiang GuoDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jianhua LiDepartment of Cardiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Ying ZhuDepartment of Cardiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yanming LiDepartment of Cardiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jingzhou JiangSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, China.
Rui ZuoDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Wei XuDepartment of Radiology, Jinling Hospital, Nanjing Medical University, 305 Zhongshan East Road, Nanjing, China.
Junqing MaDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Chao LiDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jialuo YangDepartment of Radiology, Jinling School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210002, China.
Yuting LiuDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Minjie ZhaoDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Di TianDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xinran WangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jinwei SunSchool of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, China.
Bingqian WuDepartment of Radiology, Jinling Hospital, Nanjing Medical University, 305 Zhongshan East Road, Nanjing, China.
Conghong WangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Pengfei JiangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jun ZhangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jian ZhongDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Changsheng ZhouDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Dongna YiDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xueqin BaoDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jun CaiDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yingqi ChenDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Xiaoqing ChengDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Haowen GongData and Statistics Division of Department of Critical Care Medcine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yongyue WeiCenter for Public Health and Epidemic Preparedness and Response, Peking University, 38 Xueyuan Road, Haidian District, Beijing, China.
Yuxiu LiuData and Statistics Division of Department of Critical Care Medcine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Long Jiang ZhangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. kevinzhlj@163.com.ORCID http://orcid.org/0000-0002-6664-7224

Funding

Social Development - Key Projects BE2020699special fund for clinical research project 22LCYY-LH2
6 · The paper itself

Abstract

backgroundLipid management based on cardiovascular risk level is the cornerstone of primary prevention of coronary artery disease (CAD), while the accuracy and adherence of traditional cardiovascular risk stratification have been questioned. Prevention strategies based on imaging screening for atherosclerotic plaques are found to be more objective and adherent in recent studies. This trial aims to investigate the role of coronary computed tomography angiography (CCTA) in guiding the primary prevention of CAD in a randomized controlled design.

methodsApproximately 3400 middle-aged asymptomatic community participants will be recruited and randomized in a 1:1 ratio to a traditional cardiovascular risk score-guided (usual care group) or CCTA-guided (CCTA group) strategy. Participants with cardiovascular disease, prior lipid-lowering therapy, CCTA contraindication, or serious diseases that affect life span will be excluded. The intervention strategy includes blood pressure, blood glucose, and lipid management and lifestyle modifications. Blood pressure and glucose targets and lifestyle modification recommendations keep the same in both strategies, while lipid management is personalized based on traditional risk level or CCTA results, respectively. The primary outcome is the proportion of participants taking lipid-lowering medication regularly at both 6 and 12 months. The secondary outcomes include the proportion of participants achieving low-density lipoprotein cholesterol lowering targets at 12 months, mean changes in lipid levels from baseline to 12 months, barriers to adherence, adverse reactions related to CCTA examination, and cardiovascular events. DISCUSSION: The study is the first randomized clinical trial to examine the effectiveness of a CCTA-guided versus a traditional risk score-guided primary prevention strategy in an asymptomatic community-based population.

trial registrationClinicalTrials.gov NCT05725096. Registered on 2 February 2023.

Indexed as

Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseAsymptomatic DiseasesChinaEast Asian PeopleFemaleHeart Disease Risk FactorsHumansHypolipidemic AgentsLipidsMaleMiddle AgedPrimary PreventionRandomized Controlled Trials as TopicRisk AssessmentHypolipidemic AgentsLipidsCardiovascular diseaseCommunity populationCoronary computed tomographic angiographyLipid managementPrimary prevention

Identifiers

PMID39350195
PMCPMC11440714

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.