Evidence mapPaperPMID 39350413Full record

ReviewCurrent pharmaceutical biotechnology2025

Biomarkers and Novel Therapies of Diabetic Neuropathy: An Updated Review.

Namra Aziz, Shital Vijay Nehere, Rishika Sinha, Rajeev Satyarthy, Harshit Prajapati, Uttam Prasad Panigrahy, Mukesh Chandra Sharma, Pankaj Kumar, Pranay Wal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Namra AzizDepartment of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), NH-19, Bhauti Road, Kanpur, UP, 209305, India.ORCID 0000-0003-1774-1043
Shital Vijay NehereDepartment of Pharmacy, M.C.E. Society's, Allana College of Pharmacy, Azam Campus, Camp, Pune, 411001, India.
Rishika SinhaDepartment of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), NH-19, Bhauti Road, Kanpur, UP, 209305, India.
Rajeev SatyarthyDepartment of Pharmacy, Government Pharmacy Institute, Agamkuan, Patna, Bihar, India.
Harshit PrajapatiDepartment of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), NH-19, Bhauti Road, Kanpur, UP, 209305, India.
Uttam Prasad PanigrahyDepartment of Pharmacy, Faculty of Pharmaceutical science, Assam down town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, India.
Mukesh Chandra SharmaSchool of Pharmacy, Devi Ahilya Vishwavidalaya, Indore, 452001, India.
Pankaj KumarDepartment of Pharmacology, Adesh Institute of Pharmacy and Biomedical Sciences, Adesh University, NH-7, Barnala Road, Bathinda, 151001, India.
Pranay WalDepartment of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), NH-19, Bhauti Road, Kanpur, UP, 209305, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic neuropathy is a persistent consequence of the biochemical condition known as diabetes mellitus. As of now, the identification and management of diabetic neuropathy continue to be problematic due to problems related to the safety and efficacy of existing therapies. This study examines biomarkers, molecular and cellular events associated with the advancement of diabetic neuropathy, as well as the existing pharmacological and non-pharmacological treatments employed. Furthermore, a holistic and mechanism-centric drug repurposing approach, antioxidant therapy, Gene and Cell therapies, Capsaicin and other spinal cord stimulators and lifestyle interventions are pursued for the identification, treatment and management of diabetic neuropathy. An extensive literature survey was done on databases like PubMed, Elsevier, Science Direct and Springer using the keywords "Diabetic Neuropathy", "Biomarkers", "Cellular and Molecular Mechanisms", and "Novel Therapeutic Targets". Thus, we may conclude that non-pharmacological therapies along with palliative treatment, may prove to be crucial in halting the onset of neuropathic symptoms and in lessening those symptoms once they have occurred.

Indexed as

Diabetic NeuropathiesAnimalsAntioxidantsBiomarkersHumansAntioxidantsBiomarkersbiomarkerscellular and molecular mechanismDiabetic neuropathydrug repurposinglifestyle interventions.novel therapeutic targets

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.