Evidence map›Paper›PMID 39351379›Full record

ArticleERJ open research2024

1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study.

Olivia C Leavy, Richard J Russell, Ewen M Harrison, Nazir I Lone, Steven Kerr, Annemarie B Docherty, Aziz Sheikh, Matthew Richardson, Omer Elneima, Neil J Greening and 63 more

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Article in ERJ open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors.

Olivia C LeavyDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Richard J RussellThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-0195-0812
Ewen M HarrisonCentre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Nazir I LoneThe Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0003-2707-2779
Steven KerrCentre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Annemarie B DochertyCentre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Aziz SheikhThe Usher Institute, University of Edinburgh, Edinburgh, UK.
Matthew RichardsonThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Omer ElneimaThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-2480-8840
Neil J GreeningThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-0453-7529
Victoria Claire HarrisThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Linzy Houchen-WolloffCentre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-Respiratory, University of Leicester, Leicester, UK.
Hamish J C McAuleyThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0001-8997-0764
Ruth M SaundersThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Marco SerenoThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Aarti ShikotraNIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Amisha SingapuriThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Raminder AulSt George's University Hospitals NHS Foundation Trust, London, UK.
Paul BeirneThe Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Charlotte E BoltonUniversity of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0002-9578-2249
Jeremy S BrownUCL Respiratory, Department of Medicine, University College London, Rayne Institute, London, UK.
Gourab ChoudhuryUniversity of Edinburgh, Edinburgh, UK.
Nawar Diar BakerlyManchester Metropolitan University, Manchester, UK.
Nicholas EasomInfection Research Group, Hull University Teaching Hospitals, Hull, UK.
Carlos EchevarriaThe Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Jonathan FuldDepartment of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Nick HartLane Fox Respiratory Service, Guy's and St Thomas NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-6863-585X
John R HurstUniversity College London, London, UK.ORCID https://orcid.org/0000-0002-7246-6040
Mark JonesClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-6308-6014
Dhruv ParekhUniversity of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-1508-8362
Paul PfefferBarts Health NHS Trust, London, UK.
Najib M RahmanOxford University Hospitals NHS Foundation Trust, Oxford, UK.
Sarah Rowland-JonesUniversity of Sheffield, Sheffield, UK.
Ajay M ShahKings College London, London, UK.
Dan G WoottonInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Caroline JolleyKings College London, London, UK.ORCID https://orcid.org/0000-0003-3538-2451
A A Roger ThompsonUniversity of Sheffield, Sheffield, UK.ORCID https://orcid.org/0000-0002-0717-4551
Trudie ChalderDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
Melanie J DaviesUniversity Hospitals of Leicester NHS Trust, Leicester, UK.
Anthony De SoyzaPopulation Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.ORCID https://orcid.org/0000-0002-8566-0344
John R GeddesNIHR Oxford Health Biomedical Research Centre, University of Oxford, Oxford, UK.
William GreenhalfLiverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Simon HellerDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Luke HowardImperial College Healthcare NHS Trust, London, UK.ORCID https://orcid.org/0000-0003-2822-210X
Joseph JacobCentre for Medical Image Computing, University College London, London, UK.ORCID https://orcid.org/0000-0002-8054-2293
R Gisli JenkinsNational Heart and Lung Institute, Imperial College London, London, UK.
Janet M LordMRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Will D-C ManRoyal Brompton and Harefield Clinical Group, Guy's and St Thomas NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-3782-659X
Gerry P McCannNIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Stefan NeubauerNIHR Oxford Health Biomedical Research Centre, University of Oxford, Oxford, UK.
Peter J M OpenshawNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-7220-2555
Joanna PorterUCL Respiratory, Department of Medicine, University College London, Rayne Institute, London, UK.ORCID https://orcid.org/0000-0002-7307-169X
Matthew J RowlandKadoorie Centre for Critical Care Research, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Janet T ScottMRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Malcolm G SempleNIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0001-9700-0418
Sally J SinghThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-9834-0366
David ThomasImperial College London, London, UK.
Mark ToshnerNIHR Cambridge Clinical Research Facility, Cambridge, UK.ORCID https://orcid.org/0000-0002-3969-6143
Keir LewisHywel Dda University Health Board, Wales, UK.
Liam G HeaneyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Andrew BriggsLondon School of Hygiene and Tropical Medicine, London, UK.
Bang ZhengLondon School of Hygiene and Tropical Medicine, London, UK.
Mathew ThorpeCentre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Jennifer K QuintNHLI, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-0149-4869
James D ChalmersUniversity of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Ling-Pei HoNIHR Oxford Biomedical Research Centre, Oxford, UK.
Alex HorsleyDivision of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-1828-0058
Michael MarksDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-7585-4743
Krisnah PoinasamyAsthma and Lung UK, London, UK.
Betty RamanOxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID https://orcid.org/0000-0002-1239-9608
Louise V WainDepartment of Population Health Sciences, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-4951-1867
Christopher E BrightlingThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Rachael A EvansThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-1667-868X

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute COVID-19 would be associated with improved health-related quality of life (HRQoL) 1 year after discharge. Methods: Adults admitted to hospital between February 2020 and March 2021 for COVID-19 and meeting current guideline recommendations for dexamethasone treatment were included using two prospective UK cohort studies (Post-hospitalisation COVID-19 and the International Severe Acute Respiratory and emerging Infection Consortium). HRQoL, assessed by the EuroQol-Five Dimensions-Five Levels utility index (EQ-5D-5L UI), pre-hospital and 1 year after discharge were compared between those receiving corticosteroids or not after propensity weighting for treatment. Secondary outcomes included patient-reported recovery, physical and mental health status, and measures of organ impairment. Sensitivity analyses were undertaken to account for survival and selection bias. Findings: Of the 1888 participants included in the primary analysis, 1149 received corticosteroids. There was no between-group difference in EQ-5D-5L UI at 1 year (mean difference 0.004, 95% CI -0.026-0.034). A similar reduction in EQ-5D-5L UI was seen at 1 year between corticosteroid exposed and nonexposed groups (mean±sd change -0.12±0.22 Interpretation: Systemic corticosteroids for acute COVID-19 have no impact on the large reduction in HRQoL 1 year after hospital discharge. Treatments to address the persistent reduction in HRQoL are urgently needed.

Identifiers

PMID39351379
PMCPMC11440406

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.