Evidence map›Paper›PMID 39353569›Full record

ArticleOpen biology2024

Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus.

Ildikó Kristó, Zoltán Kovács, Anikó Szabó, Péter Borkúti, Alexandra Gráf, Ádám Tamás Sánta, Aladár Pettkó-Szandtner, Edit Ábrahám, Viktor Honti, Zoltán Lipinszki and 1 more

Abstract read
In one paragraph

Article in Open biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Recent advances in nuclear actin research.Nucleus (Austin, Tex.) · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ildikó KristóInstitute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.ORCID 0009-0002-1371-9877
Zoltán KovácsInstitute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.
Anikó SzabóInstitute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.
Péter BorkútiInstitute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.
Alexandra GráfHCEMM-BRC Mutagenesis and Carcinogenesis Research Group, Institute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.
Ádám Tamás SántaHCEMM-BRC Mutagenesis and Carcinogenesis Research Group, Institute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.
Aladár Pettkó-SzandtnerProteomics Laboratory, HUN-REN Biological Research Centre , Szeged, Hungary.ORCID 0000-0002-9145-4686
Edit ÁbrahámMTA SZBK Lendület Laboratory of Cell Cycle Regulation, Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre , Szeged, Hungary.ORCID 0000-0002-1268-760X
Viktor HontiInstitute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.
Zoltán LipinszkiMTA SZBK Lendület Laboratory of Cell Cycle Regulation, Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre , Szeged, Hungary.ORCID 0000-0002-2067-0832
Péter VilmosInstitute of Genetics, HUN-REN Biological Research Centre , Szeged, Hungary.ORCID 0000-0001-5692-8818

Funding

DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Hungarian Academy of SciencesNational Laboratory for BiotechnologyNIH HHS P40 OD010949
6 · The paper itself

Abstract

The members of the evolutionary conserved actin-binding Ezrin, Radixin and Moesin (ERM) protein family are involved in numerous key cellular processes in the cytoplasm. In the last decades, ERM proteins, like actin and other cytoskeletal components, have also been shown to be functional components of the nucleus; however, the molecular mechanism behind their nuclear activities remained unclear. Therefore, our primary aim was to identify the nuclear protein interactome of the single

Indexed as

Cell NucleusDrosophila ProteinsHeat-Shock ResponseMicrofilament ProteinsProtein BindingActinsAnimalsDrosophila melanogasterGene Expression RegulationHumansMediator ComplexMembrane ProteinsTranscription FactorsActinsDrosophila ProteinsMediator ComplexMembrane ProteinsMicrofilament Proteinsmoesinmoesin, DrosophilaTranscription Factorsactingene expressionheat shockmediatormoesinnucleus

Identifiers

PMID39353569
PMCPMC11444770

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.