Evidence map›Paper›PMID 39353918›Full record

ArticleNPJ microgravity2024

Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation.

Xuechao Liang, Shanfeng Jiang, Peihong Su, Chong Yin, Wei Jiang, Junhong Gao, Zhiyong Liu, Yuhang Li, Weisi Wang, Airong Qian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuechao Liang *Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, Xi'an Key Laboratory of Special Medicine and Health Engineering, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China.
Shanfeng Jiang *Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, Xi'an Key Laboratory of Special Medicine and Health Engineering, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China.
Peihong SuShaanxi Provincial Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, Shaanxi, 710021, China.
Chong YinDepartment of Clinical Laboratory, Academician (expert) workstation, Lab of epigenetics and RNA therapy, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, P. R. China.
Wei JiangDepartment of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 710038, China.
Junhong GaoToxicology Research Center, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Zhiyong LiuToxicology Research Center, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Yuhang LiLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, Xi'an Key Laboratory of Special Medicine and Health Engineering, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China.
Weisi WangNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, P. R. China.
Airong QianLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, Xi'an Key Laboratory of Special Medicine and Health Engineering, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China. qianair@nwpu.edu.cn.
Ye TianLab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, Xi'an Key Laboratory of Special Medicine and Health Engineering, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China. tianye@nwpu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32000924, 82204543
6 · The paper itself

Abstract

Bone loss caused by long-duration spaceflight seriously affects the skeletal health of astronauts. There are many shortcomings in currently available treatments for weightlessness-induced bone loss. The aim of this study was to evaluate the preventive effect of Angelica dahuricae Radix (AR) on simulated microgravity-induced bone loss. Here, we established a hind limb unloading (HLU) mouse model and treated HLU mice with AR (2 g/kg) for 4 weeks. Results indicated that AR significantly inhibited simulated microgravity-induced bone loss. In addition, the components in AR were analyzed using UPLC-MS/MS; results showed that a total of 224 compounds were detected in AR, which mainly contained 7 classes of components. Moreover, the network pharmacological predictions suggested that active ingredients of AR might act on PTGS2 to prevent bone loss. These results elucidate the efficacy of AR in preventing microgravity-induced bone loss and its potential for use in protecting the bone health of astronauts.

Identifiers

PMID39353918
PMCPMC11445575

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.