SynthesisBMC musculoskeletal disorders2024
Genetics of hip dysplasia - a systematic literature review.
Synthesis in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Expert consensus validation of an instrument to improve the timely detection of developmental dysplasia of the hip in children.Revista medica del Instituto Mexicano del Seguro Social · 2026Pooled it
- Diagnostic Yield of Genetic Disorders in Children with Hip Dysplasia Mimicking Bilateral Legg-Calvé-Perthes Disease.Diagnostics (Basel, Switzerland) · 2026Article
- [Hip disorders in children and adolescents-an overview].Orthopadie (Heidelberg, Germany) · 2026Review
- Outcomes at 1 Year After Total Hip Arthroplasty Combined With Low Femoral Neck Osteotomy vs Subtrochanteric Osteotomy in 73 Patients With Crowe Type IV Developmental Dysplasia of the Hip: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Article
- Parental preferences for brace weaning in developmental dysplasia of the hip: a discrete choice experiment.Bone & joint open · 2025Article
- Assessment of Bone Mineral Density in Children with Developmental Dysplasia of the Hip Joint: Possible Risk Factors for Osteopenia and Osteoporosis.Medicina (Kaunas, Lithuania) · 2025Article
- Genome-Wide mRNA and lncRNA Expression Profiling to Uncover Their Role in the Molecular Pathogenesis of Developmental Dysplasia of the Hip.International journal of molecular sciences · 2025Article
- Impact of prior osteotomy and osteosynthesis on long-term outcomes after total hip arthroplasty : a 1:1 Mahalanobis distance-matched registry study of 5,392 patients.Bone & joint open · 2025Article
- Distinction Between Dysplasia, Malformation, and Deformity-Towards the Proper Diagnosis and Treatment of Hip Development Disorders.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Early Functional and Radiographic Outcomes of Stable Fixation with a Derotational Plate in Subtrochanteric Osteotomy for Crowe IV Developmental Dysplasia of the Hip.Orthopedic reviews · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all newborns. DDH increases the risk of osteoarthritis and is the cause of 30% of all total hip arthroplasties in adults < 40 years of age. We aim to explore the genetic background of DDH in order to improve diagnosis and personalize treatment.
methodsWe conducted a structured literature review using PRISMA guidelines searching the Medline, Embase and Cochrane databases. We included 31 case control studies examining single nucleotide polymorphisms (SNPs) in non-syndromic DDH.
resultsA total of 73 papers were included for full text review, of which 31 were single nucleotide polymorphism (SNP) case/control association studies. The literature review revealed that the majority of published papers on the genetics of DDH were mostly underpowered for detection of any significant association. One large genome wide association study has been published (N = 9,915), establishing GDF5 as a plausible risk factor.
conclusionsDDH is known to be congenital and heritable, with family occurrence of DDH already included as a risk factor in most screening programs. Despite this, high quality genetic research is scarce and no genetic risk factors have been soundly established, prompting the need for more research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.