Evidence mapPaperPMID 39354697Full record

ArticleAging cell2024

Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID-19.

Rodrigo J Valderrábano, Benjamin Wipper, Karol Mateusz Pencina, Marie Migaud, Yili Valentine Shang, Nancy K Latham, Monty Montano, James M Cunningham, Lauren Wilson, Liming Peng and 7 more

Abstract read
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. NADThe Journal of general virology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rodrigo J ValderrábanoResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4910-3997
Benjamin WipperResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Karol Mateusz PencinaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Marie MigaudDepartment of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA.
Yili Valentine ShangResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nancy K LathamResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Monty MontanoResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-8738-2838
James M CunninghamDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lauren WilsonResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0009-0004-0692-4201
Liming PengResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Yusnie Memish-BelevaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Avantika BhargavaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Pamela M SwainMetro International Biotech, Worcester, Massachusetts, USA.
Phoebe LehmanMetro International Biotech, Worcester, Massachusetts, USA.
Siva LavuMetro International Biotech, Worcester, Massachusetts, USA.
David J LivingstonMetro International Biotech, Worcester, Massachusetts, USA.
Shalender BhasinResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Research EducationP30AG031679 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$1.4M
Metro International BiotechNIA NIH HHS P30 AG031679NIA NIH HHS P30AG031679
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Indexed as

COVID-19HospitalizationMetabolomeNADNiacinamideSARS-CoV-2AdultAgedFemaleHumansMaleMiddle AgedSeverity of Illness IndexNADNiacinamide1‐methylnicotinamide2PYNAD+ augmentation in COVID‐19NAD+ metabolitesNAD+ turnovernicotinamideSARS‐CoV‐2 infection

Identifiers

PMID39354697
PMCPMC11634700

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.