Evidence map›Paper›PMID 39354761›Full record

ArticleCurrent aging science2025

Hypoxia-reoxygenation Extends the Lifespan of

Ferbian Milas Siswanto, Maria Dara Novi Handayani, Rita Dewi Firmasyah, Jojor Lamsihar Manalu, Adriyan Pramono

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Article in Current aging science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ferbian Milas SiswantoDepartment of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, 14440, Indonesia.ORCID 0000-0001-5034-1514
Maria Dara Novi HandayaniDepartment of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, 14440, Indonesia.
Rita Dewi FirmasyahDepartment of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, 14440, Indonesia.
Jojor Lamsihar ManaluDepartment of Physiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, 14440, Indonesia.
Adriyan PramonoDepartment of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, 50275, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo study the role of hypoxia-reoxygenation and anoxia-starvation on the lifespan of

backgroundIncreasing evidence indicates that reactive oxygen species (ROS) act as signaling molecules that promote health. Hormesis occurs when a moderate stress level induces a beneficial adaptive response, protecting organisms against subsequent exposure to severe stress.

objectivesThe objectives of this study were to explore the effects of hypoxia-reoxygenation and anoxia-starvation on the lifespan of

methodsThe

resultsThe H/R extended the lifespan of

conclusionThese results provide evidence that H/R is beneficial for lifespan and stress resistance by activating the adaptive cellular response pathway (SKN-1 and DAF-16A) toward oxidative stress.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsForkhead Transcription FactorsHormesisHypoxiaLongevityOxidative StressOxygenTranscription FactorsAnimalsReactive Oxygen SpeciesSignal TransductionTime FactorsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDNA-Binding ProteinsForkhead Transcription FactorsOxygenReactive Oxygen Speciesskn-1 protein, C elegansTranscription FactorsagingDAF-16hormesishypoxia-reoxygenationlifespanoxidative stressredox signalling.SKN-1

Identifiers

PMID39354761

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.