Evidence map›Paper›PMID 39355258›Full record

ArticleInternational medical case reports journal2024

A Case Report of Acute Liver Failure in a Child with Hepatitis a Virus and Epstein-Barr Virus Coinfection on the Background of Autoimmune Sclerosing Cholangitis.

Sergiy Kramarov, Vitalii Yevtushenko, Iryna Seriakova, Oleksandr Voronov, Nataliia Kyrytsia, Liudmyla Vladislavivna Zakordonets, Valerii Shadrin, Claudia Shatrova, Nataliia Savostikova, Volodymyr Zhezhera

Abstract readCase Reports
In one paragraph

Article in International medical case reports journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sergiy KramarovDepartment of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine.ORCID 0000-0003-2919-6644
Vitalii YevtushenkoDepartment of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine.ORCID 0000-0002-6610-8394
Iryna SeriakovaDepartment of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine.ORCID 0000-0002-2793-6584
Oleksandr VoronovDepartment of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine.ORCID 0009-0003-3637-9956
Nataliia KyrytsiaDepartment of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine.ORCID 0009-0006-5079-0292
Liudmyla Vladislavivna ZakordonetsDepartment of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine.ORCID 0000-0002-3567-860X
Valerii ShadrinDepartment of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine.ORCID 0009-0001-1228-9484
Claudia ShatrovaDepartment of Morphology, Clinical Pathology and Forensic Medicine, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.ORCID 0000-0003-2916-5098
Nataliia SavostikovaСhildren's Pathology Department, National Specialized Children's Hospital Ministry of Health of Ukraine, Kyiv, Ukraine.ORCID 0000-0003-1300-0248
Volodymyr ZhezheraСhildren's Pathology Department, National Specialized Children's Hospital Ministry of Health of Ukraine, Kyiv, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fulminant hepatitis is a rare and severe form of acute liver failure (ALF) characterized by rapid and massive destruction of liver cells and associated with a high mortality rate. Infectious factors, in particular viral hepatitis, take a prominent place in the etiology of ALF, however, the presence of chronic liver pathology can play a significant role in the disease progression and development of ALF. Case Presentation: A 2-year-old child was hospitalized on the 4th day of the disease with manifestations of jaundice and general intoxication. The examination revealed markers of active hepatitis A virus infection and Epstein-Barr virus infection. From the seventh day of the disease, the child's condition began to progressively deteriorate due to manifestations of ALF. Despite the use of immunomodulatory and replacement therapy, the disease ended fatally on the 9th day. Pathohistological examination revealed manifestations of viral necrotic hepatitis on the background of autoimmune sclerosing cholangitis. Conclusion: The case is novel as regards the occurrence of two viral hepatitis with different modes of transmission on a background of unidentified liver disease.

Indexed as

acute liver failurechildrenEpstein-Barr virus infectionfulminant hepatitisviral hepatitis A

Identifiers

PMID39355258
PMCPMC11444069

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.