ArticleNetwork neuroscience (Cambridge, Mass.)2024
Reorganization of structural connectivity in the brain supports preservation of cognitive ability in healthy aging.
Article in Network neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Article
- Structural connectome analysis using a graph-based deep model for prediction of non-imaging variables.Frontiers in neuroscience · 2026Article
- Distinct roles of brain network flexibility in motor learning across age.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Changing cognitive chimera states in human brain networks with age: Variations in cognitive integration and segregation.PLoS computational biology · 2025Article
- Structural Connectome Analysis using a Graph-based Deep Model for Prediction of Non-Imaging Variables.bioRxiv : the preprint server for biology · 2025Article
- Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications.Frontiers in aging neuroscience · 2025Article
- Dynamic network features of functional and structural brain networks support visual working memory in aging adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Young and old adult brains experience opposite effects of acute sleep restriction on the functional connectivity network.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global population is aging rapidly, and a research question of critical importance is why some older adults suffer tremendous cognitive decline while others are mostly spared. Past aging research has shown that older adults with spared cognitive ability have better local short-range information processing while global long-range processing is less efficient. We took this research a step further to investigate whether the underlying structural connections, measured in vivo using diffusion magnetic resonance imaging (dMRI), show a similar shift to support cognitive ability. We analyzed the structural connectivity streamline probability (representing the probability of connection between regions) and nodal efficiency and local efficiency regional graph theory metrics to determine whether age and cognitive ability are related to structural network differences. We found that the relationship between structural connectivity and cognitive ability with age was nuanced, with some differences with age that were associated with poorer cognitive outcomes, but other reorganizations that were associated with spared cognitive ability. These positive changes included strengthened local intrahemispheric connectivity and increased nodal efficiency of the ventral occipital-temporal stream, nucleus accumbens, and hippocampus for older adults, and widespread local efficiency primarily for middle-aged individuals.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.