ArticleDeutsches Arzteblatt international2024
The Incidence and Risk Factors of Persis tent Opioid Use After Surgery—A Retrospective Secondary Data Analysis.
Article in Deutsches Arzteblatt international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- General practitioners' decision-making strategies in the pharmacological treatment of musculoskeletal pain: A qualitative interview study.The European journal of general practice · 2025Article
- North American and European practices for opioid-sparing and opioid-free anaesthesia: a cross-sectional survey.BJA open · 2025Article
- The Complexity of Perioperative Opioid Therapy.Deutsches Arzteblatt international · 2025Article
- In Reply.Deutsches Arzteblatt international · 2025Article
- Observational
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk of persistent postoperative opioid use (PPOU) and its association with the type of surgery are still unclear in Germany.
methodsWe conducted a nationwide retrospective cohort study on the basis of claims data from BARMER, a statutory health insurance carrier in Germany. Opioid-naive adults who did not have cancer and who underwent inpatient surgery in 2018 were included in the study. The operations were divided into 103 categories. PPOU was defined as the prescribing of opioids between post - operative days 1 and 90 and also between postoperative days 91 and 180 after hospital discharge. Patient-associated risk factors in the 12 months before surgery were investigated.
results203 327 patients were included. 1.4% had PPOU (95% confidence interval [1.4; 1.5]). There were major differences between operation groups: major amputations and orthopedic procedures carried the greatest risk for the development of PPOU. The type of surgery had a larger effect on the risk of PPOU than preexisting risk factors (explained variance 22.3% vs. 14.3%). Among such factors, alcohol abuse and preexisting treatment with antidepressant drugs were associated with the highest risk for PPOU (odds ratios [OR] 1.515 [1.277; 1.797] and 2.131 [1.943; 2.336]).
conclusionThe incidence of PPOU in Germany is low (1.4%). The type of surgery plays an important role in its development.
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