ArticleProceedings of the National Academy of Sciences of the United States of America2024
Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Inverse-scattering of absorptive samples via beam propagation.bioRxiv : the preprint server for biology · 2026Article
- Retina-Inspired Bi-Based Terahertz Photonic Neuromorphic Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comparison of Chlorophyll and Bacteriochlorophyll Ultrafast Transient Absorption Spectra and Kinetics.Molecules (Basel, Switzerland) · 2026Article
- Deprotonation of retinal Schiff base and structural dynamics in the early photoreaction of primate blue cone visual pigment.Biophysical journal · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
The ultrafast photochemical reaction mechanism, transient spectra, and transition kinetics of the human blue cone visual pigment have been recorded at room temperature. Ultrafast time-resolved absorption spectroscopy revealed the progressive formation and decay of several metastable photo-intermediates, corresponding to the Batho to Meta-II photo-intermediates previously observed with bovine rhodopsin and human green cone opsin, on the picosecond to millisecond timescales following pulsed excitation. The experimental data reveal several interesting similarities and differences between the photobleaching sequences of bovine rhodopsin, human green cone opsin, and human blue cone opsin. While Meta-II formation kinetics are comparable between bovine rhodopsin and blue cone opsin, the transition kinetics of earlier photo-intermediates and qualitative characteristics of the Meta-I to Meta-II transition are more similar for blue cone opsin and green cone opsin. Additionally, the blue cone photo-intermediate spectra exhibit a high degree of overlap with uniquely small spectral shifts. The observed variation in Meta-II formation kinetics between rod and cone visual pigments is explained based on key structural differences.
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Registered trials
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