ArticleCell metabolism2025
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data.
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In one paragraph
Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
–field-weighted citation impact
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Who cites it
36 citing papers in PubMed.
- Article
- Article
- A functional missense variant iniScience · 2026Article
- The comparative cell physiology of stem cell-derived and primary human β cells.Nature reviews. Endocrinology · 2026Review
- p21-senescent cells drive pancreatic islet dysfunction through targetable paracrine signaling in type 2 diabetes.JCI insight · 2026Article
- Nutrient and non-nutrient regulators of insulin secretion.Nature reviews. Endocrinology · 2026Review
- From pancreas and islet resources to diabetes insights.Diabetologia · 2026Review
- Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience.Diabetes · 2026Article
- Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects.The EMBO journal · 2026Article
- Heterogeneous endocrine cell composition defines human islet functional phenotypes.Nature communications · 2026Article
- Article
- 5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes.Nature communications · 2026Article
- Persistent organic pollutant concentrations in human pancreas correlate with markers of beta cell dysfunction.Nature communications · 2026Article
- Biological sex affects human islet gene expression and mitochondrial function in type 2 diabetes.Endocrinology · 2026Article
- RNA-seq at different stages of human pancreatic β cell differentiation reveals proliferation dynamics and SMAD9 in directing β cell fate.Cell death & disease · 2026Article
- Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells.Diabetologia · 2026Article
- A web tool for easy and versatile analysis of human endocrine pancreas single-cell RNAseq data.Diabetes, obesity & metabolism · 2026Article
- Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes.Nature metabolism · 2026Article
- Article
- Crosstalk between the aryl hydrocarbon receptor and hypoxia-inducible factor 1α pathways in human islet models.Islets · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Jessica D EwaldInstitute of Parasitology, McGill University, Montreal, QC, Canada; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yao LuInstitute of Parasitology, McGill University, Montreal, QC, Canada.
Cara E EllisAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Jessica WortonAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Jelena KolicDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Shugo SasakiDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
Dahai ZhangDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
Theodore Dos SantosAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Aliya F SpigelmanAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Austin BautistaAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Xiao-Qing DaiAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
James G LyonAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Nancy P SmithAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
Jordan M WongAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Varsha RajeshDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA.
Han SunDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA.
Seth A SharpDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA.
Jason C RogalskiDepartment of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Renata MoravcovaDepartment of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Haoning H CenDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Jocelyn E Manning FoxAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
HumanIslets.com Consortium
Ella AtlasEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Jennifer E BruinDepartment of Biology & Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.
Erin E MulvihillDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada.
C Bruce VerchereDepartment of Surgery, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Leonard J FosterDepartment of Biochemistry & Molecular Biology, Michael Smith Laboratories, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Anna L GloynDepartment of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.
James D JohnsonDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Andrew R PepperAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Francis C LynnDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
Jianguo XiaInstitute of Parasitology, McGill University, Montreal, QC, Canada. Electronic address: jeff.xia@mcgill.ca.
Patrick E MacDonaldAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada; Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI, USA. Electronic address: pmacdonald@ualberta.ca.
Funding
The Human Pancreas Analysis Program for Type 2 DiabetesU01DK123594 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Robert Babak Faryabi, KLAUS H KAESTNER · 2019 to 2026
$25.0MPenn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8MBridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5MSupplement to Integrated Program for Human Pancreas Procurement and AnalysisUC4DK112232 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., POWERS, ALVIN C · 2016 to 2020
$8.4MHuman Pancreas Analysis Program-T2DU01DK123716 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., BOTTINO, RITA · 2019 to 2024
$6.6MLinking islet cell function and identity from in vitro to in situU01DK120447 · NIDDK · UNIVERSITY OF ALBERTA · PI ARROJO E DRIGO, RAFAEL, LUNDBERG, EMMA · 2018 to 2021
$3.0MIdentifying variants causal for Type 2 Diabetes in Major human populationsU01DK085545 · NIDDK · UNIVERSITY OF OXFORD · PI CHAN, JULIANA CN, EBRAHIM, SHAH BRIAN · 2009 to 2013
$2.8MIntegrating genome-scale data to reveal causal mechanisms in type 2 diabetesU01DK105535 · NIDDK · UNIVERSITY OF OXFORD · PI GLOYN, ANNA LOUISE · 2015 to 2019
$1.7MNIDDK NIH HHS U01 DK085545NIDDK NIH HHS U01 DK105535NIDDK NIH HHS U01 DK120447NIDDK NIH HHS U01 DK123594NIDDK NIH HHS U01 DK123716NIDDK NIH HHS UC4 DK112217NIDDK NIH HHS UC4 DK112232NIDDK NIH HHS UM1 DK126185Wellcome Trust 200837/Z/16/Z
Abstract
HumanIslets.com supports diabetes research by offering easy access to islet phenotyping data, analysis tools, and data download. It includes molecular omics, islet and cellular function assays, tissue processing metadata, and phenotypes from 547 donors. As it expands, the resource aims to improve human islet data quality, usability, and accessibility.
Indexed as
Islets of LangerhansDatabases, FactualDiabetes MellitusHumansPhenotype
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.