Evidence map›Paper›PMID 39357800›Full record

ReviewRevista espanola de cardiologia (English ed.)2025

Recent advances in precision nutrition and cardiometabolic diseases.

Miguel A Martínez-González, Francisco J Planes, Miguel Ruiz-Canela, Estefanía Toledo, Ramón Estruch, Jordi Salas-Salvadó, Rafael Valdés-Más, Pedro Mena, Olga Castañer, Montse Fitó and 10 more

Abstract readReview
In one paragraph

Review in Revista espanola de cardiologia (English ed.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. From Food to Clinic: Mapping FoodOn to the UMLS to Enable Nutritional Decision Support.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Miguel A Martínez-GonzálezCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Universidad de Navarra, Departamento de Medicina Preventiva y Salud Pública, Pamplona, Navarra, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States. Electronic address: mamartinez@unav.es.
Francisco J PlanesTecnun Escuela de Ingeniería, Departamento de Ingeniería Biomédica y Ciencias, Universidad de Navarra, San Sebastián, Guipúzcoa, Spain.
Miguel Ruiz-CanelaCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Universidad de Navarra, Departamento de Medicina Preventiva y Salud Pública, Pamplona, Navarra, Spain.
Estefanía ToledoCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Universidad de Navarra, Departamento de Medicina Preventiva y Salud Pública, Pamplona, Navarra, Spain.
Ramón EstruchCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain; Departamento de Medicina Interna, Instituto de Investigaciones Biomédicas August Pi Sunyer (IDIBAPS), Hospital Clínico, Universidad de Barcelona, Barcelona, Spain.
Jordi Salas-SalvadóCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain; Instituto de Investigación Sanitaria Pere i Virgili, Departamento de Bioquímica y Biotecnología, Unidad de Nutrición Humana Universidad Rovira i Virgili, Reus, Tarragona, Spain.
Rafael Valdés-MásImmunology Department, Weizmann Institute of Science, Rehovot, Israel.
Pedro MenaDipartimento di Scienze degli Alimenti e del Farmaco, Universitá di Parma, Parma, Italy.
Olga CastañerCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain.
Montse FitóCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain; Unidad de Riesgo Cardiovascular y Nutrición, Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, Spain.
Clary ClishBroad Institute of MIT and Harvard, Cambridge, Massachusetts, United States.
Rikard LandbergDivision of Food and Nutrition Science, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.
Clemens WittenbecherDepartment of Life Sciences, SciLifeLab, Chalmers University of Technology, Gothenburg, Sweden.
Liming LiangDepartments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.
Marta Guasch-FerréDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States; Department of Public Health and Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Rosa M Lamuela-RaventósGrup de recerca antioxidants naturals: polifenols, Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain; Institut de Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), Barcelona, Spain.
Dong D WangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.
Nita ForouhiMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Cristina RazquinCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Navarra, Spain; Universidad de Navarra, Departamento de Medicina Preventiva y Salud Pública, Pamplona, Navarra, Spain.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Metabolomics Core for the Dietary Biomarkers Development Center at Harvard UniversityU2CDK129670 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI LIANG, LIMING · 2021 to 2025
$7.0M
Mediterranean diet, Metabolites, and Cardiovascular DiseaseR01HL118264 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI HU, FRANK B, LAMUELA-RAVENTÓS, ROSA · 2013 to 2025
$6.8M
The Gut Microbiome and Personalized Mediterranean Diet Interventions for Cardiometabolic Disease PreventionR01NR019992 · NINR · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, DONG · 2021 to 2025
$3.8M
The Microbiome-Gut-Brain Axis and Personalized Mediterranean Diet Interventions for Alzheimer's Dementia PreventionRF1AG083764 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CORELLA, DOLORES, RUIZ-CANELA, MIGUEL · 2024 to 2024
$2.5M
Lifestyle Interventions, metabolites, microbiome, and diabetes riskR01DK127601 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI HU, FRANK B, RUIZ-CANELA, MIGUEL · 2021 to 2024
$1.9M
Dietary Interventions, Metabolites, and Risk of Type 2 DiabetesR01DK102896 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI HU, FRANK B, MARTINEZ GONZALEZ, MIGUEL A. · 2014 to 2017
$1.9M
Mediterranean Diet, Polyphenol-Rich Foods, Gut Microbiota and Type 2 DiabetesR00DK119412 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, DONG · 2020 to 2022
$747k
Mediterranean Diet, Polyphenol-Rich Foods, Gut Microbiota and Type 2 DiabetesK99DK119412 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI WANG, DONG · 2018 to 2019
$181k
NHLBI NIH HHS R01 HL118264NIA NIH HHS RF1 AG083764NIDDK NIH HHS K99 DK119412NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R00 DK119412NIDDK NIH HHS R01 DK102896NIDDK NIH HHS R01 DK127601NIDDK NIH HHS U2C DK129670NINR NIH HHS R01 NR019992
6 · The paper itself

Abstract

A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.

Indexed as

Cardiovascular DiseasesPrecision MedicineHumansCardiopatía isquémicaCardiovascular diseaseDiabetes mellitus tipo 2Dieta mediterráneaEnfermedad cerebrovascularEpidemiología de la nutriciónIschemic heart diseaseMediterranean dietMetabolómicaMetabolomicsNutrición de precisiónNutritional epidemiologyPrecision nutritionType 2 diabetes

Identifiers

PMID39357800
PMCPMC11875914

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.