Evidence map›Paper›PMID 39358025›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Molecular and Cellular Mechanisms of Motor Circuit Development.

Paschalis Kratsios, Niccolò Zampieri, Robert Carrillo, Kota Mizumoto, Lora B Sweeney, Polyxeni Philippidou

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Regulation of motor neuron differentiation in thebioRxiv : the preprint server for biology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paschalis KratsiosDepartment of Neurobiology, University of Chicago, Chicago, Illinois 60637 pkratsios@uchicago.edu pxp282@case.edu.ORCID 0000-0002-1363-9271
Niccolò ZampieriMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin 13125, Germany.ORCID 0000-0002-2228-9453
Robert CarrilloNeuroscience Institute, University of Chicago, Chicago, Illinois 60637.ORCID 0000-0002-2067-9861
Kota MizumotoDepartment of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Lora B SweeneyInstitute of Science and Technology Austria, Klosterneuburg 3400, Austria.ORCID 0000-0001-9242-5601
Polyxeni PhilippidouDepartment of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106 pkratsios@uchicago.edu pxp282@case.edu.ORCID 0000-0002-0733-3591

Funding

Genetic Control of Respiratory Motor Circuit Development, Connectivity and MaintenanceR01NS114510 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Polyxeni Philippidou · 2020 to 2026
$3.0M
IgSF protein interactions drive specificity in circuit wiring and synaptic elaborationR01NS123439 · NINDS · UNIVERSITY OF CHICAGO · PI CARRILLO, ROBERT ARNULFO · 2021 to 2025
$2.1M
Hox-dependent mechanisms for establishment and maintenance of motor neuron terminal identityR01NS116365 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS · 2020 to 2024
$2.0M
NINDS NIH HHS R01 NS114510NINDS NIH HHS R01 NS116365NINDS NIH HHS R01 NS123439
6 · The paper itself

Abstract

Motor circuits represent the main output of the central nervous system and produce dynamic behaviors ranging from relatively simple rhythmic activities like swimming in fish and breathing in mammals to highly sophisticated dexterous movements in humans. Despite decades of research, the development and function of motor circuits remain poorly understood. Breakthroughs in the field recently provided new tools and tractable model systems that set the stage to discover the molecular mechanisms and circuit logic underlying motor control. Here, we describe recent advances from both vertebrate (mouse, frog) and invertebrate (nematode, fruit fly) systems on cellular and molecular mechanisms that enable motor circuits to develop and function and highlight conserved and divergent mechanisms necessary for motor circuit development.

Indexed as

Motor NeuronsAnimalsHumansNerve Netdevelopmentinterneuronsmotor circuitsmotor neuronsspinal cordsynaptic specificityterminal selectors

Identifiers

PMID39358025
PMCPMC11450535

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.