Evidence map›Paper›PMID 39358395›Full record

ArticleScientific reports2024

Synergistic effects of thermally reduced graphene oxide/zinc oxide composite material on microbial infection for wound healing applications.

A Hassen, E A Moawed, Rehab Bahy, A B El Basaty, S El-Sayed, Ahmed I Ali, A Tayel

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A HassenPhysics Department, Faculty of Science, Fayoum University, El Fayoum, 63514, Egypt. ash02@fayoum.edu.eg.
E A MoawedPhysics Department, Faculty of Science, Fayoum University, El Fayoum, 63514, Egypt.
Rehab BahyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, El Fayoum, 63514, Egypt.
A B El BasatyBasic Science Department, Faculty of Technology and Education, Helwan University, Saraya El Koba, El Sawah Street, Cairo, 11281, Egypt.
S El-SayedPhysics Department, Faculty of Science, Fayoum University, El Fayoum, 63514, Egypt.
Ahmed I AliBasic Science Department, Faculty of Technology and Education, Helwan University, Saraya El Koba, El Sawah Street, Cairo, 11281, Egypt.
A TayelBasic Science Department, Faculty of Technology and Education, Helwan University, Saraya El Koba, El Sawah Street, Cairo, 11281, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections originating from pathogenic microorganisms can significantly impede the natural wound-healing process. To address this obstacle, innovative bio-active nanomaterials have been developed to enhance antibacterial capabilities. This study focuses on the preparation of nanocomposites from thermally reduced graphene oxide and zinc oxide (TRGO/ZnO). The hydrothermal method was employed to synthesize these nanocomposites, and their physicochemical properties were comprehensively characterized using X-ray diffraction analysis (XRD), High-resolution transmission electron microscopy (HR-TEM), Fourier-transform infrared (FT-IR), Raman spectroscopy, UV-vis, and field-emission scanning electron microscopy (FE-SEM) techniques. Subsequently, the potential of TRGO/ZnO nanocomposites as bio-active materials against wound infection-causing bacteria, including Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, was evaluated. Furthermore, the investigated samples show disrupted bacterial biofilm formation. A reactive oxygen species (ROS) assay was conducted to investigate the mechanism of nanocomposite inhibition against bacteria and for further in-vivo determination of antimicrobial activity. The MTT assay was performed to ensure the safety and biocompatibility of nanocomposite. The results suggest that TRGO/ZnO nanocomposites have the potential to serve as effective bio-active nanomaterials for combating pathogenic microorganisms present in wounds.

Indexed as

Anti-Bacterial AgentsGraphiteNanocompositesWound HealingZinc OxideAnimalsBiofilmsEscherichia coliHumansMicrobial Sensitivity TestsPseudomonas aeruginosaReactive Oxygen SpeciesSpectroscopy, Fourier Transform InfraredStaphylococcus aureusWound InfectionX-Ray DiffractionAnti-Bacterial Agentsgraphene oxideGraphiteReactive Oxygen SpeciesZinc OxideAntibacterial activityCharacterizationsHydrothermal synthesisOptical propertiesPathogenic microorganismTRGO/ZnO nanocomposites

Identifiers

PMID39358395
PMCPMC11447095

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.