Evidence map›Paper›PMID 39358471›Full record

ArticleScientific reports2024

EZH2 specifically regulates ISL1 during embryonic urinary tract formation.

Enrico Mingardo, Jeshurun C Kalanithy, Gabriel Dworschak, Nina Ishorst, Öznur Yilmaz, Tobias Lindenberg, Ronja Hollstein, Tim Felger, Pierre-Olivier Angrand, Heiko Reutter and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Enrico MingardoInstitute of Anatomy and Cell Biology, Medical Faculty, University of Bonn, 53115, Bonn, Germany.
Jeshurun C KalanithyInstitute of Anatomy and Cell Biology, Medical Faculty, University of Bonn, 53115, Bonn, Germany.
Gabriel DworschakInstitute of Human Genetics, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Nina IshorstInstitute of Human Genetics, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Öznur YilmazInstitute of Neuroanatomy, Medical Faculty, University of Bonn, 53115, Bonn, Germany.
Tobias LindenbergInstitute of Neuroanatomy, Medical Faculty, University of Bonn, 53115, Bonn, Germany.
Ronja HollsteinInstitute of Human Genetics, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Tim FelgerInstitute of Human Genetics, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
Pierre-Olivier AngrandUniv. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, F-59000, France.
Heiko Reutter *Institute of Human Genetics, Medical Faculty, University of Bonn, 53127, Bonn, Germany.
Benjamin Odermatt *Institute of Anatomy and Cell Biology, Medical Faculty, University of Bonn, 53115, Bonn, Germany. b.odermatt@uni-bonn.de.

Funding

BONFOR O-120.0001BONFOR O-167.0023Deutsche Forschungsgemeinschaft OD 102/1-3Deutsche Forschungsgemeinschaft RE 1723/1-3Else Kröner-Fresenius Foundation Graduate School Q614.0754
6 · The paper itself

Abstract

Isl1 has been described as an embryonic master control gene expressed in the pericloacal mesenchyme. Deletion of Isl1 from the genital mesenchyme in mice leads to an ectopic urethral opening and epispadias-like phenotype. Using genome wide association methods, we identified ISL1 as the key susceptibility gene for classic bladder exstrophy (CBE), comprising epispadias and exstrophy of the urinary bladder. The most significant marker (rs6874700) identified in our recent GWAS meta-analysis achieved a p value of 1.48 × 10

Indexed as

Enhancer of Zeste Homolog 2 ProteinLIM-Homeodomain ProteinsTranscription FactorsZebrafishAnimalsBladder ExstrophyGene Expression Regulation, DevelopmentalGenome-Wide Association StudyHumansPromoter Regions, GeneticUrinary TractZebrafish ProteinsEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanezh2 protein, zebrafishinsulin gene enhancer binding protein Isl-1LIM-Homeodomain ProteinsTranscription FactorsZebrafish ProteinsClassic bladder exstrophyEZH2Gene regulationHEK293ISL1PromoterZebrafish

Identifiers

PMID39358471
PMCPMC11447050

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.