Evidence map›Paper›PMID 39358505›Full record

ArticleNature2024

CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells.

Tyson J Ruetz, Angela N Pogson, Chloe M Kashiwagi, Stephanie D Gagnon, Bhek Morton, Eric D Sun, Jeeyoon Na, Robin W Yeo, Dena S Leeman, David W Morgens and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Isolation of postnatal human neural stem cells.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tyson J RuetzDepartment of Genetics, Stanford University, Stanford, CA, USA.
Angela N Pogson *Department of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6927-2456
Chloe M Kashiwagi *Department of Genetics, Stanford University, Stanford, CA, USA.
Stephanie D GagnonDepartment of Genetics, Stanford University, Stanford, CA, USA.
Bhek MortonDepartment of Genetics, Stanford University, Stanford, CA, USA.
Eric D SunDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8805-9864
Jeeyoon NaDepartment of Genetics, Stanford University, Stanford, CA, USA.
Robin W YeoDepartment of Genetics, Stanford University, Stanford, CA, USA.
Dena S LeemanDepartment of Genetics, Stanford University, Stanford, CA, USA.
David W MorgensDepartment of Genetics, Stanford University, Stanford, CA, USA.
C Kimberly TsuiDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3807-5329
Amy LiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Michael C BassikDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5185-8427
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA, USA. abrunet1@stanford.edu.ORCID 0000-0002-4608-6845

Funding

Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARGARET A. GOODELL · 2011 to 2026
$29.3M
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Proteostasis in the aging brainR01AG056290 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE, FRYDMAN, JUDITH · 2017 to 2021
$3.2M
NIAID NIH HHS T32 AI007290NIA NIH HHS P01 AG036695NIA NIH HHS R01 AG056290NIGMS NIH HHS T32 GM007790
6 · The paper itself

Abstract

Ageing impairs the ability of neural stem cells (NSCs) to transition from quiescence to proliferation in the adult mammalian brain. Functional decline of NSCs results in the decreased production of new neurons and defective regeneration following injury during ageing

Indexed as

AgingCRISPR-Cas SystemsNeural Stem CellsAnimalsBrainCells, CulturedCellular SenescenceFemaleGene Knockout TechniquesGlucoseGlucose Transporter Type 4HEK293 CellsHumansMaleMiceNerve RegenerationGlucoseGlucose Transporter Type 4Slc2a4 protein, mouse

Identifiers

PMID39358505
PMCPMC11525198

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.