Evidence map›Paper›PMID 39358521›Full record

ArticleNature2024

Whole-brain annotation and multi-connectome cell typing of Drosophila.

Philipp Schlegel, Yijie Yin, Alexander S Bates, Sven Dorkenwald, Katharina Eichler, Paul Brooks, Daniel S Han, Marina Gkantia, Marcia Dos Santos, Eva J Munnelly and 26 more

Abstract readValidation Study
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers.

0numbers the graph read from it
0cells of the map it votes in
231citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

231 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cell-type-specific circadian and light-responsive transcriptional dynamics in adultProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Repair Manual of a Fruit Fly Brain.International journal of molecular sciences · 2026
    Review

171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Philipp SchlegelNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-5633-1314
Yijie YinDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Alexander S BatesNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-1195-0445
Sven DorkenwaldComputer Science Department, Princeton University, Princeton, NJ, USA.
Katharina EichlerDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7833-8621
Paul BrooksDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Daniel S HanNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-9088-1651
Marina GkantiaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Marcia Dos SantosDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Eva J MunnellyDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Griffin BadalamenteDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Laia Serratosa CapdevilaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Varun A SaneDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Alexandra M C FragniereDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Ladann KiassatDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Markus W PleijzierNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-7297-4547
Tomke StürnerNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-4054-0784
Imaan F M TamimiDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Christopher R DunneDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Irene SalgarellaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Alexandre JavierDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Siqi FangDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7979-5170
Eric PerlmanYikes, Baltimore, MD, USA.ORCID 0000-0001-5542-1302
Tom Kazimierskazmos, Dresden, Germany.
Sridhar R JagannathanDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Amy R SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0001-9684-0156
Claire E McKellarPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
FlyWire Consortium
Marta CostaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5948-3092
H Sebastian SeungComputer Science Department, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8591-6733
Mala MurthyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-3063-3389
Volker HartensteinMolecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Davi D BockDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, USA. dbock@uvm.edu.ORCID 0000-0002-8218-7926
Gregory S X E JefferisNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK. jefferis@mrc-lmb.cam.ac.uk.ORCID 0000-0002-0587-9355

Funding

Lineage-associated wiring properties of Drosphila brain neuronsR01NS054814 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARTENSTEIN, VOLKER, LOUIS, MATTHIEU R. P. J. C. G. · 2006 to 2025
$6.6M
Structure and Function of a Cubic Millimeter of Cortex: Crowdsourcing for Proofreading and DiscoveryRF1MH123400 · NIMH · PRINCETON UNIVERSITY · PI SEUNG, HYUNJUNE SEBASTIAN · 2020 to 2020
$6.4M
Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Molecular and Neural Mechanisms Regulating Foraging and Food IntakeR35GM133698 · NIGMS · CORNELL UNIVERSITY · PI Nilay Yapici · 2019 to 2026
$2.9M
Neural Circuit Mechanisms Underlying Dynamic Stimulus SelectionDP2EY032737 · NEI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KIM, SUNG SOO · 2020 to 2020
$2.3M
Automating whole brain connectomics: development, validation, and application of an open toolkitRF1MH120679 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOCK, DAVI · 2019 to 2019
$1.9M
NEI NIH HHS DP2 EY032737NIGMS NIH HHS R35 GM133698NIMH NIH HHS RF1 MH120679NIMH NIH HHS RF1 MH123400NINDS NIH HHS R01 NS054814NINDS NIH HHS U24 NS126935Wellcome Trust 200846/Z/16/ZWellcome Trust 220343Wellcome Trust 221300Wellcome Trust 225192
6 · The paper itself

Abstract

The fruit fly Drosophila melanogaster has emerged as a key model organism in neuroscience, in large part due to the concentration of collaboratively generated molecular, genetic and digital resources available for it. Here we complement the approximately 140,000 neuron FlyWire whole-brain connectome

Indexed as

BrainConnectomeData CurationDrosophila melanogasterNeuronsAnimalsAtlases as TopicFemaleHeuristicsMaleMushroom BodiesNeural InhibitionReproducibility of Results

Identifiers

PMID39358521
PMCPMC11446831

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.