ArticleNature genetics2024
Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.
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Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
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Who cites it
12 citing papers in PubMed.
- Article
- Advancing risk gene discovery across the allele frequency spectrum.HGG advances · 2026Review
- Epigenetic modulation of prostate cancer disparities in men with African ancestry.Nature reviews. Urology · 2026Review
- Factors Associated With Risk Stratification and Overall Survival of Black South African Men With Non-Metastatic Prostate Cancer.Cancer medicine · 2026Article
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- Comparative Blood-Based Transcriptomic Profiles of Prostate Cancer Patients from South Africa and the USA: A Cross-Sectional Pilot Study.Journal of Cancer · 2026Article
- Downregulation of ANPEP Is Associated with Aggressive Prostate Cancer and Poor Disease-specific Outcomes.European urology open science · 2026Article
- A Prospective Validation of the Decipher Genomic Classifier in Men With Early Localized Prostate Cancer: The VANDAAM Study.Journal of the National Comprehensive Cancer Network : JNCCN · 2025Observational
- IP-SNPs-seq links noncoding risk alleles to lineage transcription factor programs in prostate cancer.Cellular and molecular life sciences : CMLS · 2025Article
- Driving Global Health equity and precision medicine through African genomic data.Human molecular genetics · 2025Article
- Accelerating cancer genomics research in Sub-Saharan Africa.Frontiers in oncology · 2025Article
- A landscape review with novel criteria to evaluate microbial drivers for cancer: priorities for innovative research targeting excessive cancer mortality in sub-Saharan Africa.Frontiers in cellular and infection microbiology · 2025Review
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Authors and funding
60 authors.
Rohini JanivaraSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0634-2357
Wenlong C ChenStrengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ujani HazraSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-3132-6487
Shakuntala BaichooUniversity of Mauritius, Réduit, Mauritius.ORCID http://orcid.org/0000-0002-9335-1939
Ilir AgalliuDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0002-6248-5790
Paidamoyo KachambwaCentre for Proteomic and Genomic Research, Cape Town, South Africa.
Corrine N SimontiSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Lyda M BrownSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6793-9851
Saanika P TambeSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Michelle S KimSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Maxine HarlemonSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Mohamed JallohUniversité Cheikh Anta Diop de Dakar, Dakar, Senegal.ORCID http://orcid.org/0000-0002-2190-328X
Dillon MuzondiwaCentre for Proteomic and Genomic Research, Cape Town, South Africa.
Daphne NaidooCentre for Proteomic and Genomic Research, Cape Town, South Africa.
Olabode O AjayiCentre for Proteomic and Genomic Research, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-9496-4227
Nana Yaa Snyper37 Military Hospital, Accra, Ghana.ORCID http://orcid.org/0000-0003-1653-8211
Lamine NiangUniversité Cheikh Anta Diop de Dakar, Dakar, Senegal.
Halimatou DiopUniversité Cheikh Anta Diop de Dakar, Dakar, Senegal.
Medina NdoyeUniversité Cheikh Anta Diop de Dakar, Dakar, Senegal.
James E MensahKorle-Bu Teaching Hospital and University of Ghana Medical School, Accra, Ghana.ORCID http://orcid.org/0000-0003-4133-1722
Afua O D AbrahamsKorle-Bu Teaching Hospital and University of Ghana Medical School, Accra, Ghana.ORCID http://orcid.org/0000-0003-0649-3996
Richard BiritwumKorle-Bu Teaching Hospital and University of Ghana Medical School, Accra, Ghana.
Andrew A AdjeiDepartment of Pathology, University of Ghana Medical School, Accra, Ghana.
Akindele O AdebiyiCollege of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID http://orcid.org/0000-0003-1869-7910
Olayiwola ShittuCollege of Medicine, University of Ibadan, Ibadan, Nigeria.
Olufemi OgunbiyiCollege of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID http://orcid.org/0000-0002-8748-2879
Sikiru AdebayoCollege of Medicine, University of Ibadan, Ibadan, Nigeria.
Maxwell M NwegbuCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Centre, Abuja, Nigeria.
Hafees O AjibolaCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Centre, Abuja, Nigeria.
Olabode P OluwoleCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Centre, Abuja, Nigeria.
Mustapha A JamdaCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Centre, Abuja, Nigeria.
Audrey PentzStrengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Christopher A HaimanKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0097-9971
Petrus V SpiesFaculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
André van der MerweFaculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
Stephen WatyaUro Care, Kampala, Uganda.
Alexander LubwamaUro Care, Kampala, Uganda.
Mazvita MuchengetiNational Cancer Registry, National Institute for Communicable Diseases a Division of the National Health Laboratory Service, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-1955-923X
Sean DohertyDivision of Urology, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Natalie SmythSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
David LounsburyDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Brian FortierDana-Farber Cancer Institute, Boston, MA, USA.
Thomas E RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Judith S JacobsonHerbert Irving Comprehensive Cancer Center, Columbia University, New York City, NY, USA.
Alfred I NeugutHerbert Irving Comprehensive Cancer Center, Columbia University, New York City, NY, USA.
Ann W HsingStanford Cancer Institute, Stanford University, Stanford, CA, USA.
Alexander GusevDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7980-4620
Oseremen I Aisuodionoe-ShadrachCollege of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Centre, Abuja, Nigeria.ORCID http://orcid.org/0000-0001-7436-6337
Maureen JoffeStrengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ben Adusei37 Military Hospital, Accra, Ghana.
Serigne M GueyeUniversité Cheikh Anta Diop de Dakar, Dakar, Senegal.
Pedro W FernandezFaculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-8728-9032
Jo McBrideCentre for Proteomic and Genomic Research, Cape Town, South Africa.
Caroline AndrewsDana-Farber Cancer Institute, Boston, MA, USA.
Lindsay N PetersenCentre for Proteomic and Genomic Research, Cape Town, South Africa.
Joseph Lachance *School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. joseph.lachance@biology.gatech.edu.ORCID http://orcid.org/0000-0002-4650-3741
Timothy R Rebbeck *Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. timothy_rebbeck@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-4799-1900
Funding
Segregation and Racial Disparities in Prostate CancerP50CA105641 · UNIVERSITY OF PENNSYLVANIA · 2003 to 2005
$5.0MGenomic Diversity of Prostate Cancer Across the African DiasporaR01CA259200 · NCI · DANA-FARBER CANCER INST · 2023 to 2025
$2.6MNCI NIH HHS P20 CA233255NCI NIH HHS P50 CA105641NCI NIH HHS R01 CA259200NCI NIH HHS U01 CA184374NIGMS NIH HHS R35 GM133727U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA257328U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01CA184374U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM133727
Abstract
Men of African descent have the highest prostate cancer incidence and mortality rates, yet the genetic basis of prostate cancer in African men has been understudied. We used genomic data from 3,963 cases and 3,509 controls from Ghana, Nigeria, Senegal, South Africa and Uganda to infer ancestry-specific genetic architectures and fine-map disease associations. Fifteen independent associations at 8q24.21, 6q22.1 and 11q13.3 reached genome-wide significance, including four new associations. Intriguingly, multiple lead associations are private alleles, a pattern arising from recent mutations and the out-of-Africa bottleneck. These African-specific alleles contribute to haplotypes with odds ratios above 2.4. We found that the genetic architecture of prostate cancer differs across Africa, with effect size differences contributing more to this heterogeneity than allele frequency differences. Population genetic analyses reveal that African prostate cancer associations are largely governed by neutral evolution. Collectively, our findings emphasize the utility of conducting genetic studies that use diverse populations.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideProstatic NeoplasmsAfrica South of the SaharaAllelesBlack PeopleCase-Control StudiesGene FrequencyGenetics, PopulationHaplotypesHumansMale
Identifiers
PMID
39358599What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.