ArticleJournal of ovarian research2024
Effect of body mass index on ovarian reserve and ART outcomes in infertile women: a large retrospective study.
Article in Journal of ovarian research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Melatonin improved the outcomes of women with ART: a systematic review and meta-analysis of randomized trials.Frontiers in reproductive health · 2025Pooled it
- Reevaluating statistical methods for proportion-based laboratory outcomes in assisted reproduction.Journal of ovarian research · 2026Review
- Effects of Supervised Physiotherapy-Based Exercise on Ovarian Reserve and Spontaneous Pregnancy in Women with Diminished Ovarian Reserve: A Controlled Pilot Study.Life (Basel, Switzerland) · 2026Article
- Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology.Frontiers in endocrinology · 2026Article
- Triglycerides and ovarian response in diminished ovarian reserve: a two-sample mendelian randomization and clinical mediation study.Frontiers in endocrinology · 2026Article
- Construction and Validation of a Clinical Pregnancy Outcome Prediction Model for Infertility Treatment Using IVF/ICSI: A Retrospective Study Based on 11,449 Cases.Frontiers in endocrinology · 2026Article
- Clinical characteristics and associated risk factors for diminished ovarian reserve among Chinese women: a matched case-control study.Frontiers in endocrinology · 2026Article
- Impact of BMI on pregnancy outcomes in PCOS patients undergoing ultralong GnRH-a protocol with blastocyst transfer.European journal of medical research · 2025Article
- Role of inflammatory blood parameters from complete blood count in predicting ovarian follicular density in cancer patients undergoing ovarian tissue cryopreservation.Journal of ovarian research · 2025Observational
- Obesity: pathophysiology and therapeutic interventions.Molecular biomedicine · 2025Review
- Building a predictive model for pregnancy outcomes in ART patients based on AMH, FORT, HCG day EMT, and clinical characteristics.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundObesity poses a significant global health challenge, with profound implications for women's reproductive health. The relationship between ovarian reserve and body mass index (BMI) remains a subject of debate. While obesity is generally associated with poorer outcomes in assisted reproductive technology (ART), the evidence remains inconclusive. This study aimed to investigate the effect of pre-pregnancy BMI on ovarian reserve and ART outcomes in infertile patients.
methodsWe conducted a retrospective cohort study involving women who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) procedures at Tongji Hospital between 2016 and 2023. The study included 30,746 initial fresh cycles and 5,721 singleton deliveries. Patients were stratified by age and further categorized into four BMI groups: lean (< 18.5 kg/m²), normal weight (18.5-24.9 kg/m²), overweight (25.0-29.9 kg/m²), and obese (≥ 30.0 kg/m²). The primary endpoints of the study were pregnancy and perinatal outcomes. To explore the association between BMI and these outcomes, we adjusted for relevant confounding factors and utilized multivariate linear regression models, complemented by multifactorial logistic regression analyses.
resultsAnti-Müllerian hormone (AMH) levels were significantly lower in the overweight and obese groups compared to the normal weight group. After adjusting for age, a negative correlation was found between AMH and BMI in the age subgroups of 20-30 and 30-35 years. Among women aged 20-35 years, those in the overweight and obese groups had significantly fewer retrieved oocytes, mature oocytes, and two-pronuclear (2PN) embryos than their normal weight counterparts. Despite these differences, pregnancy outcomes in the overweight and obese groups were comparable to those in the normal weight group across all age categories. Additionally, obesity was linked to an increased risk of gestational diabetes mellitus, hypertensive disorders of pregnancy, and macrosomia.
conclusionsAn age-related decrease in AMH levels was evident with increasing BMI. Although being overweight or obese is associated with poorer embryo and perinatal outcomes, it does not seem to have a substantial impact on fertility.
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