Evidence map›Paper›PMID 39359104›Full record

ArticleJournal of the American Chemical Society2024

Coupling and Activation of the β1 Adrenergic Receptor - The Role of the Third Intracellular Loop.

Xingyu Qiu, Kin Chao, Siyuan Song, Yi-Quan Wang, Yi-An Chen, Sarah L Rouse, Hsin-Yung Yen, Carol V Robinson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Non-canonical GScientific reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingyu QiuPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, U.K.
Kin ChaoDepartment of Life Sciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.
Siyuan SongPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, U.K.
Yi-Quan WangInstitute of Biological Chemistry, Academia Sinica, Taipei, 115024, Taiwan.
Yi-An ChenInstitute of Biological Chemistry, Academia Sinica, Taipei, 115024, Taiwan.
Sarah L RouseDepartment of Life Sciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.
Hsin-Yung YenPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, U.K.ORCID 0000-0002-6612-3324
Carol V RobinsonPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3QZ, U.K.ORCID 0000-0001-7829-5505

Funding

Wellcome Trust
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) belong to the most diverse group of membrane receptors with a conserved structure of seven transmembrane (TM) α-helices connected by intracellular and extracellular loops. Intracellular loop 3 (ICL3) connects TM5 and TM6, the two helices shown to play significant roles in receptor activation. Herein, we investigate the activation and signaling of the β

Identifiers

PMID39359104
PMCPMC11487556

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.