Evidence map›Paper›PMID 39360803›Full record

ArticleeLife2024

Recording γ-secretase activity in living mouse brains.

Steven S Hou, Yuya Ikegawa, Yeseo Kwon, Natalia Wieckiewicz, Mei C Q Houser, Brianna Lundin, Brian J Bacskai, Oksana Berezovska, Masato Maesako

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Steven S Hou *MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.
Yuya Ikegawa *MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.
Yeseo KwonMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.
Natalia WieckiewiczMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.
Mei C Q HouserMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.
Brianna LundinMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.
Brian J BacskaiMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.
Oksana BerezovskaMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.ORCID https://orcid.org/0000-0003-4898-5788
Masato MaesakoMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.ORCID https://orcid.org/0000-0002-1970-2462

Funding

TRANSGENICS AND PRESENILIN FUNCTIONP01AG015379 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BEREZOVSKA, OKSANA · 1998 to 2023
$51.3M
Role of PS1 in neurodegenerationRF1AG044486 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BEREZOVSKA, OKSANA · 2019 to 2019
$3.2M
Role of PS1 in neurodegenerationR01AG044486 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BEREZOVSKA, OKSANA · 2014 to 2018
$2.5M
A unique subpopulation of wild-type neurons recapitulating FAD phenotypesR01AG079838 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Masato Maesako · 2023 to 2026
$2.1M
Optical probe and instrumentation development for in vivo near-infrared fluorescence imaging of Alzheimer's diseaseK01AG072046 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Steven S. Hou · 2022 to 2026
$637k
BrightFocus Foundation A2019056FNIA NIH HHS AG015379NIA NIH HHS AG044486NIA NIH HHS AG072046NIA NIH HHS AG079838NIA NIH HHS K01 AG072046NIA NIH HHS P01 AG015379NIA NIH HHS R01 AG044486NIA NIH HHS R01 AG079838NIA NIH HHS RF1 AG044486
6 · The paper itself

Abstract

γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity on a cell-by-cell basis in live neurons

Indexed as

Amyloid Precursor Protein SecretasesBrainFluorescence Resonance Energy TransferAnimalsBiosensing TechniquesMiceMicroscopy, ConfocalNeuronsAmyloid Precursor Protein SecretasesbiosensorFörster resonance energy transferFRETin vivomouseneuroscienceγ-secretase

Identifiers

PMID39360803
PMCPMC11449482

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.