Evidence map›Paper›PMID 39361641›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Calcineurin-mediated dephosphorylation stabilizes E2F1 protein by suppressing binding of the FBXW7 ubiquitin ligase subunit.

Yuki Sato, Makoto Habara, Shunsuke Hanaki, Takahiro Masaki, Haruki Tomiyasu, Yosei Miki, Masashi Sakurai, Masahiro Morimoto, Daigo Kobayashi, Tatsuo Miyamoto and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Calcineurin in cancer signaling networks.Nagoya journal of medical science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuki Sato *Department of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.
Makoto Habara *Department of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.ORCID 0000-0001-6418-1291
Shunsuke HanakiDepartment of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.
Takahiro MasakiDepartment of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.ORCID 0000-0002-2948-0277
Haruki TomiyasuDepartment of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.
Yosei MikiDepartment of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.
Masashi SakuraiDepartment of Veterinary Pathology, Yamaguchi University, Yamaguchi 753-8511, Japan.ORCID 0000-0003-4998-1623
Masahiro MorimotoDepartment of Veterinary Pathology, Yamaguchi University, Yamaguchi 753-8511, Japan.
Daigo KobayashiDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan.
Tatsuo MiyamotoDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan.ORCID 0000-0002-1097-0647
Midori ShimadaDepartment of Veterinary Biochemistry, Yamaguchi University, Yamaguchi 753-8511, Japan.ORCID 0000-0002-2718-8600

Funding

Canon Medical Systems Corporation (Canon Medical) S22-0047Japan Society for the Promotion of Science London (JSPS) 21H02403Japan Society for the Promotion of Science London (JSPS) 24K02227MEXT | JST | Fusion Oriented REsearch for disruptive Science and Technology (FOREST) JPMJFR2065
6 · The paper itself

Abstract

The transcription factor E2F1 serves as a regulator of the cell cycle and promotes cell proliferation. It is highly expressed in cancer tissues and contributes to their malignant transformation. Degradation by the ubiquitin-proteasome system may help to prevent such overexpression of E2F1 and thereby to suppress carcinogenesis. A detailed understanding of the mechanisms underlying E2F1 degradation may therefore inform the development of new cancer treatments. We here identified SCF

Indexed as

CalcineurinE2F1 Transcription FactorF-Box-WD Repeat-Containing Protein 7AnimalsCell Line, TumorHEK293 CellsHumansMicePhosphorylationProtein BindingProtein StabilityProteolysisTacrolimusUbiquitinationCalcineurinE2F1 protein, humanE2F1 Transcription FactorF-Box-WD Repeat-Containing Protein 7FBXW7 protein, humanTacrolimuscalciumdephosphorylationE2F1FBXW7protein stability

Identifiers

PMID39361641
PMCPMC11474076

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.