Evidence map›Paper›PMID 39362671›Full record

ArticleThe European respiratory journal2024

Lung structure and longitudinal change in cardiac structure and function: the MESA COPD Study.

Emilia A Hermann, Yifei Sun, Eric A Hoffman, Norrina B Allen, Bharath Ambale-Venkatesh, David A Bluemke, J Jeffrey Carr, Steven M Kawut, Martin R Prince, Sanjiv J Shah and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Emilia A HermannDepartment of Medicine, Columbia University Medical Center, New York, NY, USA eah2191@cumc.columbia.edu.ORCID https://orcid.org/0000-0003-3428-0728
Yifei SunDepartment of Biostatistics, Columbia University Medical Center, New York, NY, USA.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, IA, USA.ORCID https://orcid.org/0000-0001-8456-9437
Norrina B AllenDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Bharath Ambale-VenkateshDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
David A BluemkeDepartment of Radiology, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0002-8323-8086
J Jeffrey CarrDepartment of Radiology, Vanderbilt University, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-4398-8237
Steven M KawutDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0001-7896-0608
Martin R PrinceDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Sanjiv J ShahDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Benjamin M SmithDepartment of Medicine, Columbia University Medical Center, New York, NY, USA.
Karol E WatsonDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Joao A C LimaDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
R Graham BarrDepartment of Medicine, Columbia University Medical Center, New York, NY, USA.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Chronic obstructive pulmonary disease in non-smokersR01HL130506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH, SMITH, BENJAMIN M. · 2016 to 2025
$6.3M
Fish Oil Intake, Biomarkers and Change in Lung FunctionR01HL075476 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM · 2004 to 2008
$2.8M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
NCATS NIH HHS UL1 TR000040NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL075476NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL130506NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

backgroundLung structure and cardiac structure and function are associated cross-sectionally. The classic literature suggests relationships of airways disease to cor pulmonale and emphysema to reduced cardiac output (CO) but longitudinal data are lacking.

methodsThe Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study was a multicentre longitudinal COPD case-control study of participants 50-79 years with ≥10 pack-years smoking without clinical cardiovascular disease. Segmental airway wall area (WA) and percent emphysema were measured on computed tomography. Right and left ventricle parameters were assessed on cardiac magnetic resonance imaging (cMRI) in exams 6 years apart. Longitudinal and period cross-sectional associations were evaluated with mixed models adjusted for demographics, body size and smoking.

resultsThe 187 participants with repeated cMRI were 67±7 years old; 42% had COPD; 22% currently smoked; and the race/ethnicity distribution was 54% White, 30% Black, 14% Hispanic and 3% Asian. Greater WA at enrolment was associated with longitudinal increase in right ventricular (RV) mass (3.5 (95% CI 1.1-5.9) g per 10 mm

conclusionCardiac associations varied by lung structure over 6 years in this multi-ethnic study. Greater WA at enrolment was associated with longitudinal increases in RV mass, whereas greater percent emphysema was associated with stable decrements in LV filling and CO.

Indexed as

Heart VentriclesLungMagnetic Resonance ImagingPulmonary Disease, Chronic ObstructiveTomography, X-Ray ComputedAgedCase-Control StudiesCross-Sectional StudiesFemaleHeartHumansLongitudinal StudiesMaleMiddle AgedPulmonary EmphysemaSmoking

Identifiers

PMID39362671
PMCPMC12120402

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.