Evidence map›Paper›PMID 39362850›Full record

ArticleNature communications2024

Structural basis of α-latrotoxin transition to a cation-selective pore.

B U Klink, A Alavizargar, K S Kalyankumar, M Chen, A Heuer, C Gatsogiannis

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

B U Klink *Institute for Medical Physics and Biophysics, University Münster, Münster, Germany.ORCID 0000-0002-0946-4456
A Alavizargar *Center for Soft Nanoscience (SoN), University Münster, Münster, Germany.ORCID 0000-0002-3358-6744
K S KalyankumarInstitute for Medical Physics and Biophysics, University Münster, Münster, Germany.ORCID 0000-0002-0588-893X
M ChenInstitute for Medical Physics and Biophysics, University Münster, Münster, Germany.
A HeuerCenter for Soft Nanoscience (SoN), University Münster, Münster, Germany. andheuer@uni-muenster.de.ORCID 0000-0003-2592-0287
C GatsogiannisInstitute for Medical Physics and Biophysics, University Münster, Münster, Germany. christos.gatsogiannis@uni-muenster.de.ORCID 0000-0002-4922-4545

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 496113311Deutsche Forschungsgemeinschaft (German Research Foundation) SFB 1348 Project A01Deutsche Forschungsgemeinschaft (German Research Foundation) SFB 1348 Project A15
6 · The paper itself

Abstract

The potent neurotoxic venom of the black widow spider contains a cocktail of seven phylum-specific latrotoxins (LTXs), but only one, α-LTX, targets vertebrates. This 130 kDa toxin binds to receptors at presynaptic nerve terminals and triggers a massive release of neurotransmitters. It is widely accepted that LTXs tetramerize and insert into the presynaptic membrane, thereby forming Ca

Indexed as

Cryoelectron MicroscopyMolecular Dynamics SimulationSpider VenomsAmino Acid SequenceAnimalsBlack Widow SpiderCalciumCationsalpha-latrotoxinCalciumCationsSpider Venoms

Identifiers

PMID39362850
PMCPMC11449929

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.