Evidence map›Paper›PMID 39364061›Full record

ArticleJournal of blood disorders and malignancies2024

Obesity Promotes the Ceramide-Mediated NADPH Oxidase in Acute Myeloid Leukemia.

Weiyuan Wang, Rachel J Sabol, Alexus M Day, Tamara G Hathorn, Maria N Clark, Sara E Connell, Elena A Mantis, Mariam Traore, Jacqueline M Siciliano, Emma J Arsenault and 5 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of blood disorders and malignancies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Influences on the Hematopoietic Stem Cell Niche.SciBase hematology & blood disorders · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Weiyuan WangDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.ORCID 0000-0003-0009-0467
Rachel J SabolDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Alexus M DayDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Tamara G HathornDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Maria N ClarkDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Sara E ConnellDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Elena A MantisDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Mariam TraoreDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Jacqueline M SicilianoDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Emma J ArsenaultDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Noelle T LabrecqueDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Emily C SullivanDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Andrea L CoteDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Paul T ToranDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.
Brian M BarthDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.ORCID 0000-0002-3542-1804

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Sean Stoddart Coleman Edington · 2017 to 2026
$22.8M
Tissue Repository and Animal Models CoreP01CA171983 · NCI · UNIVERSITY OF VIRGINIA · PI LOUGHRAN, THOMAS P. · 2013 to 2024
$19.9M
Regulation of Ceramide-Based Therapeutics in Acute Myeloid LeukemiaK22CA190674 · NCI · UNIVERSITY OF NEW HAMPSHIRE · PI BARTH, BRIAN MICHAEL · 2016 to 2018
$485k
Combinatorial Decitabine and Liposomal Ceramide for Acute Myeloid LeukemiaR03CA252825 · NCI · UNIVERSITY OF NEW HAMPSHIRE · PI BARTH, BRIAN MICHAEL · 2020 to 2020
$151k
NCI NIH HHS K22 CA190674NCI NIH HHS P01 CA171983NCI NIH HHS R03 CA252825NIGMS NIH HHS P20 GM113131
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a type of blood cancer of the myeloid cell lineage. Obesity is characterized by an increase in body weight that results in excessive fat accumulation. Obesity has been associated with an increased incidence of many cancers, including blood cancers. This study evaluated the role obesity in AML progression in a novel transgenic mouse model developed by crossing Flt3

Indexed as

Acid sphingomyelinaseAcute myeloid leukemiaCeramideCeramide-1-phosphateCeramide kinaseNADPH oxidase 2Obesity

Identifiers

PMID39364061
PMCPMC11449433

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.