Evidence map›Paper›PMID 39366355›Full record

ReviewMolecular cell2024

RNA-driven phase transitions in biomolecular condensates.

Gable M Wadsworth, Sukanya Srinivasan, Lien B Lai, Moulisubhro Datta, Venkat Gopalan, Priya R Banerjee

Abstract readReview
In one paragraph

Review in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. A passive protein environment offsets RNA folding energetics in cells.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. G-Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  13. Article
  14. Single-Molecule Dwell Times in Biomolecular Condensates.bioRxiv : the preprint server for biology · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gable M WadsworthDepartment of Physics, The State University of New York at Buffalo, Buffalo, NY, USA.
Sukanya SrinivasanDepartment of Physics, The State University of New York at Buffalo, Buffalo, NY, USA.
Lien B LaiDepartment of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, OH, USA.
Moulisubhro DattaDepartment of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, OH, USA.
Venkat GopalanDepartment of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, OH, USA.
Priya R BanerjeeDepartment of Physics, The State University of New York at Buffalo, Buffalo, NY, USA. Electronic address: prbanerj@buffalo.edu.

Funding

Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence MicroscopyR35GM138186 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANERJEE, PRIYA R. · 2020 to 2025
$4.4M
American Heart Association-American Stroke Association 23IPA1054097NIGMS NIH HHS R35 GM138186
6 · The paper itself

Abstract

RNAs and RNA-binding proteins can undergo spontaneous or active condensation into phase-separated liquid-like droplets. These condensates are cellular hubs for various physiological processes, and their dysregulation leads to diseases. Although RNAs are core components of many cellular condensates, the underlying molecular determinants for the formation, regulation, and function of ribonucleoprotein condensates have largely been studied from a protein-centric perspective. Here, we highlight recent developments in ribonucleoprotein condensate biology with a particular emphasis on RNA-driven phase transitions. We also present emerging future directions that might shed light on the role of RNA condensates in spatiotemporal regulation of cellular processes and inspire bioengineering of RNA-based therapeutics.

Indexed as

Biomolecular CondensatesPhase TransitionRibonucleoproteinsRNARNA-Binding ProteinsAnimalsHumansRibonucleoproteinsRNARNA-Binding Proteinsgene regulationhelicasesliquid-liquid phase separationpercolationRNA chaperonesRNP granulesstress granules

Identifiers

PMID39366355
PMCPMC11604179

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.