Evidence map›Paper›PMID 39367160›Full record

ArticleBrain topography2024

Distinct Longitudinal Changes in EEG Measures Reflecting Functional Network Disruption in ALS Cognitive Phenotypes.

Marjorie Metzger, Stefan Dukic, Roisin McMackin, Eileen Giglia, Matthew Mitchell, Saroj Bista, Emmet Costello, Colm Peelo, Yasmine Tadjine, Vladyslav Sirenko and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain topography, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Marjorie Metzger *Academic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland. metzgerm@tcd.ie.ORCID http://orcid.org/0009-0007-5463-1931
Stefan Dukic *Academic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Roisin McMackinAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Eileen GigliaAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Matthew MitchellAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Saroj BistaAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Emmet CostelloAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Colm PeeloAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Yasmine TadjineAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Vladyslav SirenkoAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Lara McManusAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Teresa BuxoAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Antonio FasanoAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Rangariroyashe ChipikaComputational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, D02 R590 Dublin 2, Dublin 2, Ireland.
Marta Pinto-GrauAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Christina SchusterComputational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, D02 R590 Dublin 2, Dublin 2, Ireland.
Mark HeverinAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Amina CoffeyAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Michael BroderickTrinity Centre for Bioengineering, Trinity College Dublin, University of Dublin, D02 R590 Dublin 2, Dublin 2, Ireland.
Parameswaran M IyerAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Kieran MohrAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Brighid GavinAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Niall PenderAcademic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Peter BedeComputational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, D02 R590 Dublin 2, Dublin 2, Ireland.
Muthuraman MuthuramanNeural Engineering with Signal Analytics and Artificial Intelligence, Department of Neurology, University Hospital Würzburg, 97080, Würzburg, Germany.
Orla Hardiman *Academic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Bahman Nasseroleslami *Academic Unit of Neurology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Room 5.43, 152-160 Pearse Street, Dublin 2, D02 R590, Ireland.

Funding

ALS Association multi-year grant 20-IIA-546Deutsche Forschungsgemeinschaft Project-ID 424778381-TRR 295Health Research Board of Ireland Emerging Investigator Award HRB-EIA-2017-019Health Research Board of Ireland HRA-POR-2013-246; MRCG-2018-02 and HRB ILP-POR-2022-046Irish Research Council GOIPD/2015/213 to B.N. and GOIPG/2017/1014 to R.M.Irish/UK Motor Neurone Disease Research Foundation IceBucket Award; MRCG2018-02 to B.N., McManus/Apr22/888-791 to L.M. and McMackin/Oct20/972-799 to R.MScience Foundation Ireland 16/ ERCD/3854 and Royal Society/SFI URF\R1\221917 to L.M.Wellcome Trust
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is characterised primarily by motor system degeneration, with clinical evidence of cognitive and behavioural change in up to 50% of cases. We have shown previously that resting-state EEG captures dysfunction in motor and cognitive networks in ALS. However, the longitudinal development of these dysfunctional patterns, especially in networks linked with cognitive-behavioural functions, remains unclear. Longitudinal studies on non-motor changes in ALS are essential to further develop our understanding of disease progression, improve care and enhance the evaluation of new treatments. To address this gap, we examined 124 ALS individuals with 128-channel resting-state EEG recordings, categorised by cognitive impairment (ALSci, n = 25), behavioural impairment (ALSbi, n = 58), or non-impaired (ALSncbi, n = 53), with 12 participants meeting the criteria for both ALSci and ALSbi. Using linear mixed-effects models, we characterised the general and phenotype-specific longitudinal changes in brain network, and their association with cognitive performance, behaviour changes, fine motor symptoms, and survival. Our findings revealed a significant decline in [Formula: see text]-band spectral power over time in the temporal region along with increased [Formula: see text]-band power in the fronto-temporal region in the ALS group. ALSncbi participants showed widespread β-band synchrony decrease, while ALSci participants exhibited increased co-modulation correlated with verbal fluency decline. Longitudinal network-level changes were specific of ALS subgroups and correlated with motor, cognitive, and behavioural decline, as well as with survival. Spectral EEG measures can longitudinally track abnormal network patterns, serving as a candidate stratification tool for clinical trials and personalised treatments in ALS.

Indexed as

Amyotrophic Lateral SclerosisElectroencephalographyAdultAgedBrainCognitionCognitive DysfunctionDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedPhenotypeCognitive-behavioural impairmentsFunctional connectivityMotor neuron diseaseNeurodegenerationSource localisationSpectral resting-state EEG

Identifiers

PMID39367160
PMCPMC11452478

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.