Evidence map›Paper›PMID 39367169›Full record

ArticleGeroScience2025

Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss.

Sandeep M Subrahmanian, Esma I Yerlikaya, Siddharth Sunilkumar, Allyson L Toro, Christopher M McCurry, Stephanie L Grillo, Alistair J Barber, Jeffrey M Sundstrom, Michael D Dennis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sandeep M SubrahmanianDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Esma I YerlikayaDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Siddharth SunilkumarDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Allyson L ToroDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Christopher M McCurryDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Stephanie L GrilloDepartment of Ophthalmology, Penn State College of Medicine, Hershey, PA, 17033, USA.
Alistair J BarberDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Jeffrey M SundstromDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Michael D DennisDepartment of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. mdennis@psu.edu.ORCID 0000-0002-0645-6864

Funding

Redox-sensitive activation of REDD1 in diabetic retinopathyR01EY032879 · NEI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Michael D Dennis · 2021 to 2026
$3.0M
Targeting the Etiology of Diabetic RetinopathyR01EY029702 · NEI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DENNIS, MICHAEL D. · 2019 to 2023
$2.0M
Unifying Mechanism of Oxidative Stress and Inflammation in AMDR21EY035844 · NEI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DENNIS, MICHAEL D · 2024 to 2025
$460k
BrightFocus Foundation M2024006FNEI NIH HHS R01 EY029702NEI NIH HHS R01 EY032879NEI NIH HHS R21 EY035844
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in elderly populations, yet the molecular events that initiate the early retinal defects that lead to visual function deficits remain poorly understood. The studies here explored a role for the stress response protein Regulated in Development and DNA damage response 1 (REDD1) in the development of retinal pathology by using the oxidant stressor sodium iodate (NaIO

Indexed as

Macular DegenerationRetinal Pigment EpitheliumTranscription FactorsAnimalsDisease Models, AnimalIodatesMiceMice, Inbred C57BLMice, KnockoutOxidative StressReactive Oxygen SpeciesDdit4 protein, mouseIodatesReactive Oxygen Speciessodium iodateTranscription FactorsAgingDDIT4Retinal pigmented epitheliumRTP801

Identifiers

PMID39367169
PMCPMC11979080

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.