Evidence map›Paper›PMID 39367530›Full record

Trial reportPhysiological reports2024

Acute impact of inorganic nitrate supplementation after ischemia and during small muscle mass exercise in postmenopausal females: A pilot study.

Jacob T Caldwell, Alyssa Koenke, Lauren Zimmerman, Aaron E Wahl, Sarah A Fenn, Emily E Grammer, Macy E Stahl, Jason D Allen, Salvador J Jaime

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacob T CaldwellExercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin, USA.ORCID 0000-0002-2893-4986
Alyssa KoenkeExercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin, USA.
Lauren ZimmermanExercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin, USA.
Aaron E WahlExercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin, USA.
Sarah A FennExercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin, USA.
Emily E GrammerDepartment of Kinesiology, School of Education and Human Development, University of Virginia, Charlottesville, Virginia, USA.
Macy E StahlDepartment of Kinesiology, School of Education and Human Development, University of Virginia, Charlottesville, Virginia, USA.
Jason D AllenDepartment of Kinesiology, School of Education and Human Development, University of Virginia, Charlottesville, Virginia, USA.
Salvador J JaimeExercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin, USA.

Funding

University of Wisconsin-La Crosse, RSEL
6 · The paper itself

Abstract

Menopause is associated with reduced endothelial-dependent vasodilation and increased cardiovascular disease (CVD) risk. Dietary nitrate, a non-pharmacological approach, may increase vasodilatory capacity consequentially reducing CVD risk. We investigated macro- and microvascular function after acute nitrate supplementation in postmenopausal females (PMF). Vascular function was studied with flow-mediated vasodilation (FMD) and near-infrared post occlusive reactive hyperemia (PORH). Incremental handgrip exercise was performed to investigate blood flow and tissue oxygenation. We hypothesized acute dietary nitrate would not impact resting endothelial measures but would increase post ischemic vasodilation and incremental exercise blood flow. Late-phase PMF (n = 12) participated in a randomized crossover design with 140 mL of nitrate-rich (NR) beetroot juice or nitrate-poor black currant juice. Testing included a 5-min FMD, a 3-min ischemic exercise FMD, and incremental exercise at 10%, 15%, and 20% maximal voluntary contraction to measure blood flow and pressure responses. A p ≤ 0.05 was considered significant. One-way ANOVA indicated lower resting pressures, but no change to FMD, or PORH in either protocol. Two-way repeated measures ANOVA indicated NR supplementation significantly reduced mean arterial pressure at rest and during incremental exercise at all intensities without changes to blood flow. Acute nitrate is effective for resting and exercising blood pressure management in PMF.

Indexed as

Beta vulgarisDietary SupplementsExerciseIschemiaNitratesPostmenopauseAgedCross-Over StudiesFemaleFruit and Vegetable JuicesHand StrengthHumansHyperemiaMiddle AgedMuscle, SkeletalPilot ProjectsNitratesagingblood flowischemic exercisenear‐infrared spectroscopyoxygenation

Identifiers

PMID39367530
PMCPMC11452349

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.