Evidence map›Paper›PMID 39367737›Full record

ArticleIntegrative cancer therapies

The Use of Herbal Medicine and Dietary Supplements in Cancer Patients Receiving Immune Checkpoint Inhibitors: A Multicenter Cross-Sectional Study.

Fatih Kus, Deniz Can Guven, Hasan Cagri Yildirim, Baran Akagunduz, Serdar Karakaya, Osman Sutcuoglu, Elvin Chalabiyev, Arif Akyildiz, Baris Koksal, Yigit Berk Sahin and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Fatih KusHacettepe University, Medical oncology, Ankara, Turkey.ORCID 0000-0003-1650-154X
Deniz Can GuvenHacettepe University, Medical oncology, Ankara, Turkey.
Hasan Cagri YildirimHacettepe University, Medical oncology, Ankara, Turkey.
Baran AkagunduzErzincan Mengucek Gazi Education and Research Hospital, Turkey.
Serdar KarakayaAtaturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara,Turkey.
Osman SutcuogluGazi University, Medical oncology, Ankara, Turkey.
Elvin ChalabiyevHacettepe University, Medical oncology, Ankara, Turkey.
Arif AkyildizHacettepe University, Medical oncology, Ankara, Turkey.
Baris KoksalHacettepe University, Medical oncology, Ankara, Turkey.
Yigit Berk SahinHacettepe University, Department of Internal Medicine, Ankara, Turkey.
Ece KaracaHacettepe University, Department of Internal Medicine, Ankara, Turkey.
Oguz Alp KavrukHacettepe University, Department of Internal Medicine, Ankara, Turkey.
Nefise Tugce ZorHacettepe University, Department of Internal Medicine, Ankara, Turkey.
Firat SirvanHacettepe University, Department of Internal Medicine, Ankara, Turkey.
Ozan YaziciGazi University, Medical oncology, Ankara, Turkey.
Suayib YalcinHacettepe University, Medical oncology, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study aimed to assess the habits and knowledge of cancer patients regarding the use of herbal medicines and dietary supplements in cancer patients receiving immune checkpoint inhibitors (ICI).

methodsThe data of 181 cancer patients who were over 18 years old and received ICIs were collected. The usage patterns, anticipated benefits and harms, and sources of supply were evaluated by filling researcher-prepared forms.

resultsMost patients did not use any kind of herbal medicine (91.2%) or dietary supplements (75.9%) during their immunotherapy. Boosting the immune system is the primary motivation for use among users. Multivitamins are the most frequently used supplements. Family members and TV advertisements were the main sources of information, in addition to limited advice from healthcare professionals. A minority of participants reported gastrointestinal side effects. Herbal medicine and dietary supplement use were more prevalent among patients with stage IV cancer and renal cell carcinoma (RCC). DISCUSSION: This study revealed that the limited uptake of herbal medicines and dietary supplements alongside ICI treatment among cancer patients. The lack of adequate information from healthcare professionals poses potential risks to patients. Improved communication with patients, education regarding herbal medicine and dietary supplement use, potential interactions, and associated risks during ICI treatment are essential. Further research is needed to identify the specific needs of patients, anticipated benefits, and potential harms of herbal medicine and dietary supplement use, together with ICIs.

Indexed as

Dietary SupplementsImmune Checkpoint InhibitorsNeoplasmsAdultAgedCross-Sectional StudiesFemaleHerbal MedicineHumansImmunotherapyMaleMiddle AgedPhytotherapyImmune Checkpoint Inhibitorscomplementary and alternative medicineherbalimmune checkpoint inhibitors

Identifiers

PMID39367737
PMCPMC11526273

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.