Evidence map›Paper›PMID 39368285›Full record

ArticleNutrition research (New York, N.Y.)2024

Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy.

Kate Ormiston, Julie Fitzgerald, Rebecca Andridge, Maryam B Lustberg, Anne Courtney DeVries, Tonya S Orchard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition research (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kate OrmistonDivison of Medical Oncology, College of Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA.
Julie FitzgeraldDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Rebecca AndridgeDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, USA.
Maryam B LustbergDivision of Medical Oncology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Anne Courtney DeVriesDepartment of Neuroscience, School of Medicine, West Virginia University, Morgantown, West Virginia, USA.
Tonya S OrchardHuman Nutrition Program, Department of Human Sciences, College of Education and Human Ecology, The Ohio State University Columbus, Ohio, USA. Electronic address: Orchard.6@osu.edu.

Funding

Effect of n-3 fatty acids and sugars on chemotherapy-induced cognitive deficitsR01CA189947 · NCI · OHIO STATE UNIVERSITY · PI DEVRIES, ANNE COURTNEY, LUSTBERG, MARYAM B. · 2015 to 2018
$2.2M
NCI NIH HHS R01 CA189947
6 · The paper itself

Abstract

Chemotherapy-related cognitive impairment (CRCI) and affective symptoms negatively impact quality of life in breast cancer survivors. The aim of this study was to determine the efficacy of high eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) and low sucrose diets to alleviate these symptoms in a mouse model of chemotherapy. Potential mechanisms involving insulin resistance were explored. We hypothesized that diets enriched in EPA+DHA and low amounts of sucrose would protect against the impact of chemotherapy on measures of CRCI. Female C57Bl/6 mice were randomized to 1 of 4 diets (2% kcal eicosapentaenoic acid + docosahexaenoic acid [EPA+DHA]/high or low sucrose, low omega-3/high or low sucrose) for 6 weeks and treated with two injections of doxorubicin-based chemotherapy or vehicle during week 2 and 4. Behavioral tests were performed 7 days after second injection. Chemotherapy increased serum insulin and decreased body weight, locomotion and exploratory behavior (all p < .05). Low sucrose consumption resulted in better long-term memory regardless of chemotherapy or vehicle injection (p < .05). 2% EPA+DHA consumption lessened insulin resistance (p < .05); however, controlling for body weight attenuated this effect (p = .08). There were no significant differences by diet or injection on liver lipid content; however, liver lipid content was positively correlated with insulin resistance scores (p < .05). Low sucrose diets may protect long-term memory during chemotherapy. The effect of EPA+DHA on insulin resistance and affective side effects during chemotherapy requires further investigation.

Indexed as

DietDocosahexaenoic AcidsEicosapentaenoic AcidInsulin ResistanceMemory, Long-TermMice, Inbred C57BLAnimalsAntineoplastic AgentsDietary SucroseDisease Models, AnimalDoxorubicinFemaleInsulinMiceAntineoplastic AgentsDietary SucroseDocosahexaenoic AcidsDoxorubicinEicosapentaenoic AcidInsulinChemotherapyDocosahexaenoic acidEicosapentaenoic acidInsulin resistanceOmega-3 fatty acids

Identifiers

PMID39368285
PMCPMC11683824

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.