Evidence map›Paper›PMID 39369124›Full record

ArticleScientific reports2024

Genomic analysis of Enterobacteriaceae from colorectal cancer patients at a tertiary hospital in Ghana: a case-control study.

Sarah V Bachelle, Saikou Y Bah, Richmond T Addo, Antoinette A A Bediako-Bowan, Beverly Egyir, Sandra E Tsatsu, Bartholomew Dzudzor, Vincent Amarh

Abstract read
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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah V BachelleDepartment of Medical Biochemistry, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Saikou Y BahSchool of Infection & Immunity, University of Glasgow, Glasgow, UK.
Richmond T AddoCentral Laboratory, Korle-Bu Teaching Hospital, Korle-Bu, Accra, Ghana.
Antoinette A A Bediako-BowanDepartment of Surgery, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Beverly EgyirBacteriology Department, Noguchi Memorial Institute for Medical Research, Accra, Ghana.
Sandra E TsatsuDepartment of Surgery, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Bartholomew DzudzorDepartment of Medical Biochemistry, University of Ghana Medical School, Korle-Bu, Accra, Ghana. bdzudzor@ug.edu.gh.
Vincent AmarhDepartment of Medical Biochemistry, University of Ghana Medical School, Korle-Bu, Accra, Ghana. vamarh@ug.edu.gh.

Funding

BANGA-AFRICA PROJECT; UNIVERSITY OF GHANA UG-BA/SRG-011/2022
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a severe gastrointestinal cancer and a leading cause of cancer-related deaths in Ghana. The potential role of gut Enterobacteriaceae in the increasing incidence of CRC in Ghana is yet to be thoroughly investigated. In this study, Enterobacteriaceae from CRC patients and healthy control participants were analyzed by whole genome sequencing to identify genomic features that are associated with CRC. Socio-demographic data showed a significant association between age and alcohol consumption and CRC. Escherichia coli was the most abundant Enterobacteriaceae isolated from the study participants and they were predominantly intestinal commensals. Escherichia coli isolates belonging to phylogroup D encoded the highest number of virulence genes. The agn43 and int genes were widespread in Escherichia coli isolates from the CRC patients. Multilocus sequence types of potentially pathogenic Escherichia coli from the CRC patients also encoded genes involved in aggregation, adherence and biofilm formation. The ampC2 and ampH antimicrobial resistance genes were also widespread in the genome of the Escherichia coli isolates. This study highlights the virulence tendencies of Escherichia coli from CRC patients and their ability to transfer virulence determinants to other Enterobacteriaceae residing in the gut.

Indexed as

Colorectal NeoplasmsEnterobacteriaceaeTertiary Care CentersAdultAgedCase-Control StudiesEnterobacteriaceae InfectionsEscherichia coliFemaleGenome, BacterialGenomicsGhanaHumansMaleMiddle AgedVirulence FactorsVirulence FactorsAntimicrobial resistanceColorectal cancerEnterobacteriaceaeGenomicsVirulence factors

Identifiers

PMID39369124
PMCPMC11455924

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.