Evidence map›Paper›PMID 39370234›Full record

ReviewTransplantation and cellular therapy2024

Cutaneous Chronic Graft-Versus-Host Disease: Clinical Manifestations, Diagnosis, Management, and Supportive Care.

Connie R Shi, Alana L Ferreira, Manjit Kaur, David Xiang, Jean Caputo, Hannah K Choe, Nada Hamad, Edward W Cowen, Benjamin H Kaffenberger, Emily Baumrin

Abstract readReview
In one paragraph

Review in Transplantation and cellular therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Steroid-Refractory Cutaneous Graft-versus-Host Disease: a Case ReportRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2026
    Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Connie R ShiCenter for Cutaneous Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Alana L FerreiraDepartment of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Manjit KaurDepartment of Dermatology, The Ohio State University, Columbus, Ohio.
David XiangHarvard Medical School, Boston, Massachusetts.
Jean CaputoDivision of Hematology, The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio.
Hannah K ChoeDivision of Hematology, The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio.
Nada HamadDepartment of Haematology, St. Vincent's Hospital, Sydney, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia; School of Medicine, University of Notre Dame Australia, Sydney, Australia.
Edward W CowenDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Benjamin H KaffenbergerDepartment of Dermatology, The Ohio State University, Columbus, Ohio.
Emily BaumrinDepartment of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: Emily.Baumrin@pennmedicine.upenn.edu.

Funding

Study Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6M
Targeting epigenetic regulation via Bromodomain and Extraterminal (BET) domain inhibition for treatment of GVHDR01CA252469 · NCI · OHIO STATE UNIVERSITY · PI CHOE, HANNAH, RANGANATHAN, PARVATHI · 2021 to 2025
$2.0M
Development and validation of a patient-reported outcome measure to improve quality of life related to cutaneous chronic GVHDK23AR085191 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Emily Baumrin · 2025 to 2026
$348k
NCI NIH HHS R01 CA252469NIAMS NIH HHS K23 AR085191NIAMS NIH HHS P30 AR069589
6 · The paper itself

Abstract

Cutaneous chronic graft-versus-host disease (cGVHD) is associated with morbidity, mortality, and impaired quality of life after hematopoietic stem cell transplantation. The clinical features of cutaneous cGVHD are heterogeneous but can be broadly classified into nonsclerotic or sclerotic presentations. This review provides an overview of clinical presentation, diagnosis and differential diagnosis, grading, and treatment of cutaneous cGVHD. Particular attention is given to cutaneous cGVHD in skin of color, which can have unique features and is generally underrepresented in the literature leading to delays in diagnosis. Finally, an overview of long-term skin care for patients with cutaneous cGVHD is provided in order to support patients from a dermatologic perspective as they recover from cGVHD. Multidisciplinary care with frequent communication between transplant specialists and dermatologists is critical to effectively managing cutaneous cGVHD.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationSkin DiseasesChronic DiseaseDiagnosis, DifferentialHumansQuality of LifeCutaneous graft versus host disease

Identifiers

PMID39370234
PMCPMC12396616

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.