ArticlemedRxiv : the preprint server for health sciences2024
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.
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190 authors.
Luis M García-MarínBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Adrian I CamposBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Santiago Diaz-TorresSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, 4072, Australia.
Jill A RabinowitzDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Zuriel CejaBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Brittany L MitchellBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Katrina L GrasbyBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Jackson G ThorpBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Ingrid AgartzCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, 0319, Norway.
Saud AlhusainiDepartment of Neurology, Alpert Medical School of Brown University, Providence, RI, 02903, USA.
David AmesAcademic Unit Psychiatry of Old Age, University of Melbourne, Kew, VIC, 3101, Australia.
Philippe AmouyelUniversite Lille, U1167 - RID-AGE - LabEx DISTALZ - Risk factors and molecular determinants of aging diseases, Lille, F-59000, France.
Ole A AndreassenCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, 0319, Norway.ORCID 0000-0002-4461-3568
Konstantinos ArfanakisRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
Alejandro Arias VasquezDepartments of Psychiatry and Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 GA, The Netherlands.
Nicola J ArmstrongDepartment of Mathematics and Statistics, Curtin University, Perth, Australia.
Lavinia AthanasiuCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, 0319, Norway.
Mark E BastinCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom.
Alexa S BeiserDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, 02118, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98195-9458, USA.
Marco Pm BoksBrain Center University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands.
Dorret I BoomsmaVrije Universiteit, Amsterdam, 1081BT, The Netherlands.ORCID 0000-0002-7099-7972
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.
Rachel M BrouwerDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neurocience, VU Amsterdam, Amsterdam, 1081 HV, The Netherlands.
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 EN, The Netherlands.
Ralph BurkhardtInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg University, Regensburg, 93053, Germany.ORCID 0000-0003-1924-1202
Wiepke CahnDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, 3584CX, The Netherlands.
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), {Georgia State, Georgia Tech, Emory}, Atlanta, GA, 30303, USA.ORCID 0000-0001-9058-0747
Owen T CarmichaelPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Mallar ChakravartyCerebral Imaging Centre, Douglas Research Centre, Montreal, QC, H4H 1R3, Canada.
Qiang ChenLieber Institute for Brain Development, Baltimore, MD, 21205, USA.
Christopher R K ChingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, 90292, USA.
Sven CichonInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, 52428, Germany.
Benedicto Crespo-FacorroHU Virgen del Rocio, Instituto de Investigacion biomedica IBIS-CSIC, Universidad de Sevilla, CIBERSAM, Sevilla, 41013, Spain.
Fabrice CrivelloCNRS, IMN, UMR 5293, University of Bordeaux, Bordeaux, 33076, France.ORCID 0000-0001-6950-984X
Anders M DaleCenter for Multimodal Imaging and Genetics, La Jolla, CA, 92093, USA.
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, United Kingdom.
Eco Jc de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, 1081 BT, The Netherlands.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, 10538, USA.ORCID 0000-0002-8057-2505
Greig I de ZubicaraySchool of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
Stéphanie DebetteSchool of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
Charles DeCarliImaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Sacramento, CA, 95817, USA.
Chantal DepondtDepartment of Neurology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, 1070, Belgium.
Sylvane DesrivièresSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, United Kingdom.
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital, Oslo, 0450, Norway.
Stefan EhrlichTranslational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, 01307, Germany.
Susanne ErkDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, 11017, Germany.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, 0373, Norway.
Guillén FernándezDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Irina FilippiINSERM U1299, Paris Saclay University, Gif-sur-Yvette, 91190, France.
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, 6525 XD, The Netherlands.ORCID 0000-0002-3132-1996
Debra A FleischmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
Evan FletcherDepartment of Neurology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0002-9761-3131
Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID 0000-0003-0677-8158
Andreas J ForstnerInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, 52428, Germany.
Clyde FrancksDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.ORCID 0000-0002-9098-890X
Barbara FrankeDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 EN, The Netherlands.
Tian GePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Aaron L GoldmanLieber Institute for Brain Development, Baltimore, MD, 21205, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, 17475, Germany.
Robert C GreenDepartment of Medicine (Genetics), Mass General Brigham and Harvard Medical School, Boston, MA, 02115, USA.
Oliver GrimmCentral Institute of Mental Health, Mannheim, 68159, Germany.
Nynke A GroenewoldDepartment of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, 7925, South Africa.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, D-69115, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, 201, Iceland.
Asta K HåbergDepartment of Neuromedicine and Movement, NTNU Science, Trondheim, 7030, Norway.
Unn K HaukvikNorwegian Centre for Mental Health Research (NORMENT), Department of Mental Health and Addiction, University of Oslo, Oslo, 0450, Norway.ORCID 0000-0002-0363-4127
Andreas HeinzCentre for Forensic Psychiatry Research, Oslo University Hospital, Oslo, 0455, Norway.
Derrek P HibarProduct Development, Genentech, Inc., South San Francisco, CA, 94080, USA.
Saima HilalSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Jayandra J HimaliDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, 02118, USA.ORCID 0000-0003-1391-9481
Beng-Choon HoDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52246, USA.
David F HoehnMax Planck Institute of Psychiatry, Munich, 80804, Germany.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9713 GZ, The Netherlands.
Edith HoferDivision of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
Wolfgang HoffmannGerman Centre for Neurodegenerative Diseases (DZNE) - site Rostock/Greifswald, Greifswald, 17489, Germany.
Avram J HolmesDepartment of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, 08854, USA.ORCID 0000-0001-6583-803X
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.
Norbert HostenDepartment of Radiology, University Clinic Greifswald, Greifswald, 17475, Germany.
M Kamran IkramDepartments of Epidemiology and Neurology, Erasmus MC, Rotterdam, 3015 CN , The Netherlands.
Jonathan C IpserDepartment of Psychiatry and Mental Health, Neuroscience Institute, Groote Schuur Hospital, University of Cape Town, Cape Town, 7925, South Africa.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0001-7916-622X
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, 90292, USA.ORCID 0000-0003-4401-8950
Erik G JönssonCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, 0319, Norway.
Rene S KahnDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, 3584CX, The Netherlands.
Ryota KanaiAraya, Inc., Tokyo, 101-0025, Japan.
Marieke KleinDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Maria J KnolDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 GD, The Netherlands.ORCID 0000-0002-3597-1531
Lenore J LaunerIntramural Research Program, National Institute on Aging, Baltimore, MD, 21224, USA.
Stephen M LawrieDivision of Psychiatry, University of Edinburgh, Edinburgh, EH10 5HF, United Kingdom.
Stephanie Le HellardDepartment of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Phil H LeeCenter for Genomic Medicine, Mass General Brigham, Boston, MA, 02114, USA.ORCID 0000-0003-1770-3100
Hervé LemaîtreGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR 5293, CNRS, Université de Bordeaux, Bordeaux, 33076, France.ORCID 0000-0002-5952-076X
Shuo LiDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, 02118, USA.ORCID 0000-0003-2331-2448
David Cm LiewaldPPLS, University of Edinburgh, Edinburgh, EH8, United Kingdom.
Honghuang LinDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.
W T LongstrethDepartment of Neurology, University of Washington, Seattle, WA, 98104-2420, USA.
Oscar L LopezDepartments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Michelle LucianoDepartment of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.ORCID 0000-0002-7306-3008
Pauline MaillardDepartment of Neurology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0003-3516-6345
Andre F MarquandDonders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
Nicholas G MartinBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Jean-Luc MartinotUniversité Paris-Saclay; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 "Trajectoires développementales Psychiatrie", Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Université Paris Cité, Centre Borelli, Gif sur Yvette, 911.
Karen A MatherCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.
Venkata S MattayLieber Institute for Brain Development, Baltimore, MD, 21205, USA.
Katie L McMahonSchool of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, 4001, Australia.
Patrizia MecocciInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, 06132, Italy.
Ingrid MelleCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, 0319, Norway.
Andreas Meyer-LindenbergDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany.
Nazanin Mirza-SchreiberInstitute of Neurogenomics,Helmholtz Munich, 85764, Neuherberg, Germany.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, The Netherlands.
Thomas H MosleyMIND Center, Jackson, MS, 39216, USA.
Thomas W MühleisenInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, 52428, Germany.
Bertram Müller-MyhsokStatistics Genetics Group, Max Planck Institute of Psychiatry, Munich, 80804, Germany.ORCID 0000-0002-0719-101X
Susana Muñoz ManiegaCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom.ORCID 0000-0001-5185-6384
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17489, Germany.
Kwangsik NhoDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Wiro J NiessenUniversity Medical Center Groningen, Groningen, 9713GZ, The Netherlands.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, 53127, Germany.ORCID 0000-0002-8770-2464
Paul A NyquistDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Jaap OosterlaanClinical Neuropsychology section, Vrije Universiteit Amsterdam, Amsterdam, 1081 BT, The Netherlands.ORCID 0000-0002-0218-5630
Massimo PandolfoUniversité Libre de Bruxelles, Brussels, 1070, Belgium.
Tomas PausDepartments of Psychiatry and Neuroscience, Faculty of Medicine, University of Montreal, Montreal, QC, H3T 1C5, Canada.
Zdenka PausovaHospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Brenda Wjh PenninxDepartment of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, The Netherlands.
G Bruce PikeDepartments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.ORCID 0000-0001-8924-683X
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98195-9458, USA.
Benno PützTranslational Psychiatry, Munich, 80804, Germany.
Simone ReppermundCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.
Marcella D RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, 68159, Germany.
Shannon L RisacherCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Nina Romanczuk-SeiferthDepartment of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Berlin, 10117, Germany.
Rafael Romero-GarciaInstituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla/ CIBERSAM, ISCIII, Dpto. de Fisiología Médica y Biofísica, Sevilla, 41013, Spain.
Gennady V RoshchupkinDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.ORCID 0000-0002-9595-3220
Philipp G SämannMax Planck Institute of Psychiatry, Munich, 80804, Germany.
Arvin SaremiImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, 90292, USA.
Muralidharan SargurupremrajINSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, F-33000, France.
Andrew J SaykinCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-1376-8532
Lianne SchmaalCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
Helena SchmidtInstitute of Molecular Biology & Biochemistry, Gottfried Schatz Center for Signaling, Metabolism & Aging, Medical University Graz, Graz, 8010, Austria.
Reinhold SchmidtDepartment of Neurology, Medical University Graz Austria, Graz, 8023, Austria.
Peter R SchofieldNeuroscience Research Australia, Sydney, NSW, 2031, Australia.ORCID 0000-0003-2967-9662
Markus ScholzLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04103, Germany.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University, Shanghai, 200031, P.R. China.
Emanuel SchwarzDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68159, Germany.
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jean ShinThe Hospital for Sick Children, Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON, M5G 0A4, Canada.
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, WC1N 3BG, United Kingdom.
Albert V SmithIcelandic Heart Association, Kopavogur, 201, Iceland.ORCID 0000-0003-1942-5845
Jordan W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Hilkka S SoininenDepartment of Neurology, Institute of Clinical Mediciine, University of Eastern Finland, Kuopio, 70100, Finland.
Vidar M SteenDepartment of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Dan J SteinSAMRC Research Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, 7925, South Africa.
Jason L SteinDepartment of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7250, USA.ORCID 0000-0003-4829-0513
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, 90292, USA.ORCID 0000-0002-0046-4070
Arthur W TogaImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, 90292, USA.ORCID 0000-0001-7902-3755
Diana Tordesillas-GutiérrezInstituto de Física de Cantabria (CSIC-UC), Santander, E-39005, Spain.
Julian N TrollorCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.ORCID 0000-0002-7685-2977
Maria C Valdes-HernandezCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom.ORCID 0000-0003-2771-6546
Dennis van 't EntDepartment of Biological Psychology & Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, 1081 BT, The Netherlands.
Hans van BokhovenDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 EN, The Netherlands.
Dennis van der MeerCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, 0319, Norway.
Nic Ja van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.ORCID 0000-0003-3235-1633
Javier Vázquez-BourgonDepartment of Psychiatry, University Hospital Marqués de Valdecilla - IDIVAL, Santander, 39008, Spain.
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, 1081 HJ, The Netherlands.
Meike W VernooijDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, 04103, Germany.
Louis N VinkeDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, 17495, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, 11017, Germany.
Joanna M WardlawCentre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom.ORCID 0000-0002-9812-6642
Daniel R WeinbergerLieber Institute for Brain Development, Baltimore, MD, 21205, USA.
Michael W WeinerUniversity of California San Francisco, San Francisco, CA, 94121, USA.
Wei WenCentre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, 2052, Australia.ORCID 0000-0003-2753-3870
Lars T WestlyeCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, 0319, Norway.ORCID 0000-0001-8644-956X
Eric WestmanDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, 14183, Sweden.ORCID 0000-0002-3115-2977
Tonya WhiteSection on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892-1276, USA.
A Veronica WitteDepartment of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, 04103, Germany.
Christiane WolfMax Planck Institute of Psychiatry, Munich, 80804, Germany.
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
Marcel P ZwiersDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, 6525 EN, The Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 GD, The Netherlands.
Sudha SeshadriFramingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, 02118, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, 90292, USA.ORCID 0000-0002-4720-8867
Claudia L SatizabalFramingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, 02118, USA.ORCID 0000-0002-1115-4430
Sarah E MedlandBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Miguel E RenteríaBrain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.ORCID 0000-0003-4626-7248
Funding
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7MPeripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo, NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MUC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MUltrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7MKBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems BiologyU01AG072177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, DONG YOUNG, NHO, KWANGSIK TIMOTHY · 2021 to 2025
$11.2MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MMemory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9MLeveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's DiseaseR01AG057739 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI APOSTOLOVA, LIANA G, PERRY, BREA LOUISE · 2018 to 2022
$3.5MCognitive Aging, Alzheimers disease, and Cancer-related Cognitive DeclineR01AG068193 · NIA · GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE, SAYKIN, ANDREW J · 2020 to 2023
$2.8MTraining Grant on Alzheimer's Disease and ADRD at Indiana UniversityT32AG071444 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GARY E. LANDRETH, Bruce T Lamb · 2021 to 2026
$2.8MNIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG057739NIA NIH HHS R01 AG068193NIA NIH HHS T32 AG071444NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG072177NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG074879NIH HHS S10 OD032285NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH134004NINDS NIH HHS RF1 NS136995NLM NIH HHS R01 LM013463
Abstract
Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. We performed GWAS meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and, for the first time, the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signalling and brain ageing-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and ADHD. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.