Evidence map›Paper›PMID 39371966›Full record

ArticleACS omega2024

Diabetes and Cognitive Decline: An Innovative Approach to Analyzing the Biophysical and Vibrational Properties of the Hippocampus.

Maria Do Socorro Do Nascimento Amorim, Erick Rafael Dias Rates, de Araujo Costa Melo Isabela Vitoria, Joel Félix Silva Diniz Filho, Clenilton Costa Dos Santos, Ralph Santos-Oliveira, Renato Simões Gaspar, Jonas Rodrigues Sanches, Bruno Araújo Serra Pinto, Antonio Marcus de Andrade Paes and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. MAM-Mediated Mitochondrial CaBrain sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Do Socorro Do Nascimento AmorimFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.
Erick Rafael Dias RatesFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.
de Araujo Costa Melo Isabela VitoriaFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.
Joel Félix Silva Diniz FilhoFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.ORCID https://orcid.org/0000-0001-7525-2403
Clenilton Costa Dos SantosFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.
Ralph Santos-OliveiraBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro 21941906, Brazil.ORCID https://orcid.org/0000-0002-0905-481X
Renato Simões GasparCampinas State University, Translational Medicine Department, Campinas, Sao Paulo 13083888, Brazil.
Jonas Rodrigues SanchesFederal University of Maranhão, Department of Physiological Sciences, Laboratory of Experimental Physiology, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.
Bruno Araújo Serra PintoFederal University of Maranhão, Department of Physiological Sciences, Laboratory of Experimental Physiology, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.
Antonio Marcus de Andrade PaesFederal University of Maranhão, Department of Physiological Sciences, Laboratory of Experimental Physiology, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.
Luciana Magalhães Rebelo AlencarFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranhão 65080-805, Brazil.ORCID https://orcid.org/0000-0001-8210-2016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes Mellitus (DM) is a disease characterized by high blood glucose levels, known as hyperglycemia. Diabetes represents a risk factor for the development of neurodegenerative diseases, such as Alzheimer's Disease (AD), one of the most prevalent neurodegenerative diseases worldwide, which leads to progressive mental, behavioral, and functional decline, affecting many brain structures, especially the hippocampus. Here, we aim to characterize the ultrastructural, nanomechanical, and vibrational changes in hyperglycemic hippocampal tissue using atomic force microscopy (AFM) and Raman spectroscopy. DM was induced in rats by streptozotocin injection (type 1) or dietary intervention (type 2). Cryosections of the hippocampus were prepared and analyzed on an MM8 AFM (Bruker) in Peak Force Quantitative Nanomechanics mode, performing 25 μm

Identifiers

PMID39371966
PMCPMC11447714

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.