Evidence map›Paper›PMID 39372775›Full record

ArticlebioRxiv : the preprint server for biology2024

Genomic analyses identify 15 susceptibility loci and reveal

Shawna R Cook, Sanne Hugen, Jessica J Hayward, Thomas R Famula, Janelle M Belanger, Elizabeth McNiel, Hille Fieten, Anita M Oberbauer, Peter A J Leegwater, Elaine A Ostrander and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Shawna R CookBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-7967-9607
Sanne HugenExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0009-0006-3864-8680
Jessica J HaywardDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-6213-5013
Thomas R FamulaDepartment of Animal Science, University of California, Davis, CA, USA.ORCID 0000-0002-3139-9849
Janelle M BelangerDepartment of Animal Science, University of California, Davis, CA, USA.ORCID 0000-0002-3703-260X
Elizabeth McNielCummings School of Veterinary Medicine, Tufts University, Grafton, Massachusetts, USA.
Hille FietenExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-0562-6964
Anita M OberbauerDepartment of Animal Science, University of California, Davis, CA, USA.
Peter A J LeegwaterExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-4100-015X
Elaine A OstranderCancer Genetics and Comparative Genomics Branch, National Human Genome Research Center, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6075-9738
Paul J J MandigersExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-2547-6673
Jacquelyn M EvansBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID 0000-0003-1272-0059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is the fifth most common human cancer worldwide, but the genetic etiology is largely unknown. We performed a Bayesian genome-wide association study and selection analyses in a naturally-occurring canine model of GC, the Belgian Tervuren and Sheepdog breeds, to elucidate underlying genetic risk factors. We identified 15 loci with over 90% predictive accuracy for the GC phenotype. Variant filtering revealed germline putative regulatory variants for the

Indexed as

adenocarcinomaBayesian GWASBelgian SheepdogcaninedogGroenendaelMalinoisPDZRN3selectionTervuren

Identifiers

PMID39372775
PMCPMC11451740

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.