Evidence map›Paper›PMID 39372797›Full record

ArticlebioRxiv : the preprint server for biology2024

Modulation of Neuronal Excitability and Plasticity by BHLHE41 Conveys Lithium Non-Responsiveness.

Marius Stephan, Sergi Papiol, Mingyue Zhang, Jie Song, Samuel M Frommeyer, Helen Haupt, Niels Jensen, Nirmal Kannaiyan, Rajinder Gupta, Philipp Schuler and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Marius StephanDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.
Sergi PapiolDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.
Mingyue ZhangLaboratory of Molecular Psychiatry, Department of Psychiatry, University of Muenster, Germany.
Jie SongDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7357-2136
Samuel M FrommeyerLaboratory of Molecular Psychiatry, Department of Psychiatry, University of Muenster, Germany.
Helen HauptLaboratory of Molecular Psychiatry, Department of Psychiatry, University of Muenster, Germany.
Niels JensenDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.
Nirmal KannaiyanSystasy Bioscience GmbH, Munich, Germany.
Rajinder GuptaDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.
Philipp SchulerDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.
Pia PicklmannDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.
Michael McCarthyVA San Diego Healthcare System, CA, USA.
Eva SchulteInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany.
Mikael LandenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.ORCID 0000-0003-2873-8667
Volker ScheussDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.
Thomas SchulzeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany.ORCID 0000-0001-6624-2975
Weiqi ZhangLaboratory of Molecular Psychiatry, Department of Psychiatry, University of Muenster, Germany.
Moritz J RossnerDepartment of Psychiatry and Psychotherapy, Molecular and Behavioral Neurobiology, LMU University Hospital, LMU Munich, Germany.ORCID 0000-0002-0667-3420

Funding

Circadian Rhythms in Neuronal Models of Bipolar DisorderI01BX003431 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI MCCARTHY, MICHAEL JOSEPH · 2017 to 2025
–
BLRD VA I01 BX003431
6 · The paper itself

Abstract

Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium response. Among the top hits was

Identifiers

PMID39372797
PMCPMC11451663

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.