Evidence map›Paper›PMID 39374081›Full record

ArticlePhysiological genomics2025

Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention.

Helen N Jones, Baylea N Davenport, Rebecca L Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Helen N JonesDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-7356-8420
Baylea N DavenportDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-5804-2340
Rebecca L WilsonDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-3867-7784

Funding

Placental-specific therapy for fetal growth restrictionR01HD090657 · NICHD · UNIVERSITY OF FLORIDA · PI HELEN N JONES · 2017 to 2026
$2.6M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD090657NICHD NIH HHS R01 HD090657
6 · The paper itself

Abstract

The etiology of fetal growth restriction (FGR) is multifactorial, although many cases often involve placental insufficiency. Placental insufficiency is associated with inadequate trophoblast invasion, resulting in high resistance to blood flow, decreased availability of nutrients, and increased hypoxia. We have developed a nonviral, polymer-based nanoparticle that facilitates delivery and transient gene expression of human insulin-like 1 growth factor (

Indexed as

Fetal Growth RetardationGenetic TherapyInsulin-Like Growth Factor IPlacental InsufficiencyTranscriptomeTrophoblastsAnimalsDisease Models, AnimalFemaleGuinea PigsHumansNanoparticlesPlacentaPregnancyIGF1 protein, humanInsulin-Like Growth Factor Ifetal growth restrictionIGF1nanoparticleplacental insufficiencytrophoblast invasion

Identifiers

PMID39374081
PMCPMC11918312

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.