Evidence map›Paper›PMID 39374157›Full record

ArticleCNS neuroscience & therapeutics2024

Neuroprotective effects of punicalagin and/or micronized zeolite clinoptilolite on manganese-induced Parkinson's disease in a rat model: Involvement of multiple pathways.

Karema Abu-Elfotuh, Ashwaq N Abbas, Mazin A A Najm, Qutaiba A Qasim, Ahmed M E Hamdan, Amany B Abdelrehim, Ayah M H Gowifel, Aya H Al-Najjar, Ahmed M Atwa, Magy R Kozman and 10 more

Abstract read
PubMed Full text at PMC Publisher
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Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Karema Abu-ElfotuhClinical Pharmacy Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.ORCID 0000-0003-3870-3206
Ashwaq N AbbasCollege of Dentistry, University of Sulaimanyia, Kurdistan, Iraq.
Mazin A A NajmDepartment of Pharmacy, Mazaya University College, Thi-Qar, Alnasiriya, Iraq.
Qutaiba A QasimDepartment of Clinical Laboratory Sciences, College of Pharmacy, Al-Ayen Iraqi University, Thi-Qar, Iraq.
Ahmed M E HamdanFaculty of Pharmacy, Department of Pharmacy Practice, University of Tabuk, Tabuk, Saudi Arabia.ORCID 0000-0003-4930-792X
Amany B AbdelrehimBiochemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
Ayah M H GowifelPharmacology and Toxicology Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.ORCID 0000-0003-1738-7101
Aya H Al-NajjarPharmacology and Toxicology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-3588-5721
Ahmed M AtwaAl-Ayen Iraqi University, Thi-Qar, Iraq.ORCID 0000-0001-8580-4179
Magy R KozmanClinical Pharmacy Department, Faculty of Pharmacy, Misr University for Science and Technology, Giza, Egypt.ORCID 0000-0002-3637-0922
Azza S KhalilPhysiology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Amira M NegmPhysiology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Sara Nagdy Mahmoud MousaPhysiology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Amira M HamdanOceanography Department, Faculty of Science, Alexandria University, Alexandria, Egypt.ORCID 0000-0002-7220-3646
Rana H Abd El-RhmanDepartment of pharmacology & Toxicology, Faculty of Pharmacy, Sinai University - Kantara Branch, Ismailia, Egypt.
Shaimaa R AbdelmohsenAnatomy and Embryology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Amina M A TolbaAnatomy and Embryology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Heba Abdelnaser AboelsoudAnatomy and Embryology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.ORCID 0009-0000-8568-2490
Ahmad SalahuddinBiochemistry Department, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
Alshaymaa DarwishBiochemistry Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundManganism, a central nervous system dysfunction correlated with neurological deficits such as Parkinsonism, is caused by the substantial collection of manganese chloride (MnCl

objectivesTo explore the neuroprotective effects of natural compounds, namely, micronized zeolite clinoptilolite (ZC) and punicalagin (PUN), either individually or in combination, against MnCl

methodsFifty male albino rats were divided into 5 groups (Gps). Gp I was used as the control group, and the remaining animals received MnCl

resultsZC and/or PUN reversed the depletion of monoamines in the brain and decreased acetyl choline esterase activity, which primarily adjusted the animals' behavior and motor coordination. ZC and PUN restored the balance between glutamate/γ-amino butyric acid content and markedly improved the brain levels of brain-derived neurotrophic factor and nuclear factor erythroid 2-related factor 2/heme oxygenase-1 and decreased glycogen synthase kinase-3 beta activity. ZC and PUN also inhibited inflammatory and oxidative markers, including nuclear factor kappa-light-chain-enhancer of activated B cells, Toll-like receptor 4, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 and caspase-1. Bcl-2-associated X-protein and B-cell leukemia/lymphoma 2 protein (Bcl-2) can significantly modify caspase-3 expression. ZC and/or PUN ameliorated PD in rats by decreasing the levels of endoplasmic reticulum (ER) stress markers (p-protein kinase-like ER kinase (PERK), glucose-regulated protein 78, and C/EBP homologous protein (CHOP)) and enhancing the levels of an autophagy marker (Beclin-1). DISCUSSION AND

conclusionZC and/or PUN mitigated the progression of PD through their potential neurotrophic, neurogenic, anti-inflammatory, antioxidant, and anti-apoptotic activities and by controlling ER stress through modulation of the PERK/CHOP/Bcl-2 pathway.

Indexed as

ChloridesHydrolyzable TanninsNeuroprotective AgentsZeolitesAnimalsBrainDisease Models, AnimalMaleManganese CompoundsRatsChloridesclinoptiloliteHydrolyzable Tanninsmanganese chlorideManganese CompoundsNeuroprotective AgentspunicalaginZeolitesanti‐inflammatoryantioxidantautophagyendoplasmic reticulum stressmicronized zeolite clinoptiloliteoxidative stressParkinson's diseasepunicalagin

Identifiers

PMID39374157
PMCPMC11457879

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.